CHLORPHENIRAMINE, HYDROCODONE, AND PSEUDOEPHEDRINE

(KLOR fe NEER a meen, HYE droe KOE done, SOO doe ee FED rin) Brand: Cordron-HC, Cordron-HC NR, Detuss, Hydrocof-HC, Hydron PCS, Hyphed, JayCof-HC, Notuss-Forte, P-V-Tussin Syrup, Q-V Tussin, Welltuss HC, Zutripro

What is the most significant information I must know about chlorpheniramine, hydrocodone, and pseudoephedrine?

• Do not take this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. Serious, life threatening side effects can occur if you use chlorpheniramine, hydrocodone, and pseudoephedrine till the MAO inhibitor has cleared from your body.

• Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Drinking alcohol can magnify determined side effects of chlorpheniramine, hydrocodone, and pseudoephedrine.

• Till using this medicine, speak your doctor if you regularly use another medicines that create you sleepy (such as cool or allergy medication, sedatives, narcotic pain medication, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, hydrocodone, and pseudoephedrine.

• Hydrocodone may be habit-forming and must be used only by the face it was predesigned for. Never share hydrocodone with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

What is chlorpheniramine, hydrocodone, and pseudoephedrine?

• Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• Hydrocodone is a narcotic cough medicine.

• Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can reason nasal congestion (stuffy nose).

• The combination of chlorpheniramine, hydrocodone, and pseudoephedrine is used to treat runny or stuffy nose, sinus congestion, and cough caused by the general cool or flu.

• Chlorpheniramine, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking chlorpheniramine, hydrocodone, and pseudoephedrine?

• You must not use chlorpheniramine, hydrocodone, and pseudoephedrine if you are allergic to it.

• To create certain you can safely take this medicine, speak your doctor if you have any of these another conditions:

· asthma, COPD, sleep apnea, or another breathing disorder;

· liver or kidney disease;

· heart malady or tall blood pressure;

· diabetes;

· a thyroid disorder;

· curvature of the spine;

· a history of head injury or brain tumor;

· epilepsy or another seizure disorder;

· low blood pressure;

· glaucoma;

· gallbladder disease;

· Addison's malady or another adrenal gland disorders;

· enlarged prostate, urination problems;

· mental diseases; or

· a history of drug or alcohol addiction.

• FDA pregnancy category C. It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine will harm an unborn child. Hydrocodone may reason addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Speak your doctor if you are pregnant or plan to become pregnant while using chlorpheniramine, hydrocodone, and pseudoephedrine.

• It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take chlorpheniramine, hydrocodone, and pseudoephedrine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• You may take this medicine with or without food.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Store at room temperature away from moisture and heat.

• Hold track of the amount of medication used from every new bottle. Hydrocodone is a drug of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone can be fatal.

• Overdose symptoms may include extreme drowsiness, feeling restless or nervous, vomiting, stomach pain, warmth or tingly feeling, seizure (convulsions), pinpoint pupils, confusion, cool and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.

What must I avoid while taking chlorpheniramine, hydrocodone, and pseudoephedrine?

• Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

• Drinking alcohol can magnify determined side effects of chlorpheniramine, hydrocodone, and pseudoephedrine.

What are the possible side effects of chlorpheniramine, hydrocodone, and pseudoephedrine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using this medicine and call your doctor at once if you have a serious side effect such as:

· severe dizziness, anxiety, restless feeling, or nervousness;

· quick, pounding, or uneven heartbeats;

· shallow breathing, slow heartbeat;

· confusion, hallucinations, unusual thoughts or behavior;

· feeling like you might pass out;

· urinating smaller than normal or not at all;

· light bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, seizure); or

· upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· nausea, vomiting, upset stomach, constipation;

· dry mouth;

· blurred vision;

· dizziness, drowsiness;

· problems with memory or concentration;

· sleep problems (insomnia);

· ringing in your ears;

· warmth, tingling, or redness under your skin; or

· skin rash or itching.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect chlorpheniramine, hydrocodone, and pseudoephedrine?

• Speak your doctor about all another medications you use, especially:

· blood pressure medication;

· cimetidine (Tagamet);

· rifampin (Rifadin, Rifater, Rifamate, Rimactane);

· zidovudine (Retrovir, AZT);

· an antidepressant;

· a diuretic (water pill);

· medicine to treat irritable bowel syndrome;

· bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

· aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

· seizure medicine such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton);

· a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; or

· medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).

• This list is not complete and another drugs may interact with chlorpheniramine, hydrocodone, and pseudoephedrine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, hydrocodone, and pseudoephedrine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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