CHLORPHENIRAMINE AND CODEINE

(KLOR fen IR a meed and KOE deen) Brand: Codar AR, Cotab A, Cotab AX, Endacof-C, Notuss-AC, TL-Hist CM, Z-Tuss AC, Zodryl AC 25, Zodryl AC 30, Zodryl AC 35, Zodryl AC 40, Zodryl AC 50, Zodryl AC 60, Zodryl AC 80, Zodryl AC Adult

What is the most significant information I must know about chlorpheniramine and codeine?

• You must not use this medication if you have severe liver malady, inflammatory bowel malady, severe constipation, a blockage in your stomach or intestines, severe colitis or toxic megacolon, if you have a colostomy or ileostomy, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank big amounts of alcohol, or if you have a head injury or brain tumor.

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, heart malady, or a thyroid disorder.

• Do not use a cough or cool medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

• Codeine puede crear dependencia, y solamente debe ser usada por la persona para quien ha sido recetada. Mantenga la medicina en un lugar seguro donde otros no la puedan obtener.

What is chlorpheniramine and codeine?

• Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can manufacture symptoms of sneezing, itching, watery eyes, and runny nose.

• Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

• The combination of chlorpheniramine and codeine is used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the general cool, or the flu.

• Chlorpheniramine and codeine will not treat a cough that is caused by smoking, asthma, or emphysema.

• Chlorpheniramine and codeine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking chlorpheniramine and codeine?

• Do not use this medication if you have untreated or uncontrolled illness such as glaucoma, asthma or COPD, heart malady, or a thyroid disorder.

• To create certain you can safely take this medication, speak your doctor if you have any of these another conditions:

· a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;

· a heart rhythm disorder;

· a history of drug or alcohol addiction;

· sleep apnea (breathing stops during sleep);

· liver or kidney disease;

· epilepsy or another seizure disorder;

· cough with mucus, or cough caused by emphysema or chronic bronchitis;

· gallbladder disease;

· enlarged prostate or urination problems;

· an adrenal gland tumor or mess (such as Addison's disease);

· if you are dehydrated; or

· if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

• Codeine may be habit forming and must be used only by the face for whom it was predesigned. Never share this medicine with other face, especially somebody with a history of drug abuse or addiction. Hold the medicine in a seat where others can't get to it.

• FDA pregnancy category C. Codeine may reason addiction or withdrawal symptoms in a newborn if the mother takes the medicine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using the medication.

• Codeine can pass into breast milk and may harm a nursing child. The use of codeine by some nursing mothers may lead to life-threatening side effects in the child. Antihistamines may also slow breast milk manufacture. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How must I take chlorpheniramine and codeine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. This medication is generally taken for only a short time before your symptoms clear up.

• Do not take for longer than 7 days in a row. Conversation with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

• Do not give this medicine to a baby younger than 4 years old. Always ask a doctor till giving a cough or cool medication to a child. Death can occur from the misuse of cough and cool medicines in very young children.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• If you need surgery or medical trials, speak the surgeon or doctor onward of time if you have taken this medication within the past little days.

• Store at room temperature away from moisture and heat. Do not let the liquid to freeze.

• Hold track of the amount of medication used from every new bottle. Codeine is a drug of abuse and you must be aware if anyone is using your medication improperly or without a prescription.

What happens if I miss a dose?

• Since this medication is taken when needed, you may not be on a dosing schedule. If you are taking the medicine regularly, take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. An overdose of codeine can be fatal.

• Overdose symptoms may include confusion, extreme weakness, pinpoint pupils, cool and clammy skin, weak pulse, slow breathing, fainting, or breathing that stops.

• Overdose symptoms may also include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking chlorpheniramine and codeine?

• This medicine may reason blurred vision and may impair your thinking or reactions. Avoid driving or operating machinery before you know how chlorpheniramine and codeine will affect you.

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

• Do not drink alcohol while you are taking medication that contains codeine. Dangerous side effects or death can occur when alcohol is combined with a narcotic medication.

• Ask a doctor or pharmacist till using any another cool, cough, allergy, or sleep medication. Antihistamines and cough suppressants are contained in much combination medicines. Taking determined commodity together can reason you to get too many of a determined drug. Check the label to see if a medication contains an antihistamine or cough suppressant.

What are the possible side effects of chlorpheniramine and codeine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using chlorpheniramine and codeine and call your doctor at once if you have a serious side effect such as:

· confusion, mood changes, hallucinations, unusual thoughts or behavior;

· severe dizziness or drowsiness, feeling like you might pass out;

· severe nervousness, quick or uneven heart course, tremor, seizure (convulsions);

· pain or numbness in the arms or legs;

· severe stomach cramps or constipation;

· weak or shallow breathing;

· light bruising or bleeding, unusual weakness; or

· urinating smaller than normal or not at all.

• Smaller serious side effects may include:

· dizziness, drowsiness, weary feeling;

· dry mouth, nose, or throat;

· blurred vision;

· nausea, vomiting, constipation; or

· sleep problems (insomnia).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect chlorpheniramine and codeine?

• Till using chlorpheniramine and codeine, speak your doctor if you regularly use another medicines that can create you sleepy or slow your breathing (such as cool or allergy medication, narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, and medication for seizures, depression, or anxiety).

• Speak your doctor about all another medications you use, especially:

· atropine (Atreza, Sal-Tropine);

· benztropine (Cogentin);

· naloxone (Narcan, Suboxone);

· topiramate (Topamax);

· tramadol (Ultram, Ultracet);

· zonisamide (Zonegran);

· anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

· bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

· ulcer medication such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

• This list is not complete and another drugs may interact with chlorpheniramine and codeine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine and codeine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(30)