NEOSTIGMINE

(nee o STIG meen) Brand: Prostigmin Bromide

What is the most significant information I must know about neostigmine?

• You must not use this medicine if you are allergic to neostigmine or pyridostigmine (Mestinon), or if you have a bladder or bowel obstruction, or a serious stomach mess called peritonitis.

• Till taking neostigmine, speak your doctor if you have asthma, kidney malady, slow heartbeats or another heart rhythm mess, tall blood pressure, heart malady, coronary artery malady, an ulcer or another serious stomach mess, overactive thyroid, or a history of seizures.

• The amount and timing of this medication is extremely significant to the success of your treatment. Carefully follow your doctor's instructions about how many medication to take and when to take it. You may need to take neostigmine at evenly spaced intervals near the clock.

• This medicine may reason blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• Your doctor may occasionally change your doze to create certain you get the excellent results. You may be asked to hold a daily record of when you took every doze and how long the effects lasted. This will help your doctor determine if your doze needs to be adjusted.

• If you need surgery, speak the surgeon onward of time that you are using neostigmine. You may need to stop using the medication for a short time.

What is neostigmine?

• Neostigmine affects chemicals in the body that are involved in the communication between nerve impulses and muscle movement.

• Neostigmine is used to treat the symptoms of myasthenia gravis.

• Neostigmine may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking neostigmine?

• You must not use this medicine if you are allergic to neostigmine or pyridostigmine (Mestinon), or if you have a bladder or bowel obstruction, or a serious stomach mess called peritonitis.

• To create certain you can safely take neostigmine, speak your doctor if you have any of these another conditions:

· asthma;

· kidney disease;

· slow heartbeats or another heart rhythm disorder;

· tall blood pressure, heart malady, coronary artery disease;

· an ulcer or another serious stomach disorder;

· overactive thyroid; or

· a history of seizures.

• FDA pregnancy category C. It is not known whether neostigmine will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medicine. You must not take neostigmine during late pregnancy.

• It is not known whether neostigmine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using neostigmine.

How must I take neostigmine?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Take this medication with food or milk if it upsets your stomach.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact. Breaking or opening the pill may reason too many of the drug to be released at one time.

• If you need surgery, speak the surgeon onward of time that you are using neostigmine. You may need to stop using the medication for a short time.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include nausea, vomiting, diarrhea, stomach cramps, sweating, blurred vision, drooling, and weak or shallow breathing.

• Worsening muscle weakness, or no change in your myasthenia gravis symptoms, may also be signs of overdose.

What must I avoid while taking neostigmine?

• This medicine may reason blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

• Drinking alcohol can magnify drowsiness caused by neostigmine.

What are the possible side effects of neostigmine?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using neostigmine and call your doctor at once if you have any of these serious side effects:

· extreme muscle weakness;

· slurred speech, vision problems;

· feeling like you might pass out;

· severe stomach cramps or diarrhea;

· trouble breathing, cough with mucus;

· quick or slow heart rate;

· seizure (convulsions); or

· worsening or no improvement in your symptoms of myasthenia gravis.

• Smaller serious side effects may include:

· headache, drowsiness;

· mild nausea, vomiting, gas;

· urinating more than usual;

· cool sweat, warmth or tingly feeling; or

· mild rash or itching.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect neostigmine?

• Speak your doctor about all another medicines you use, especially:

· atropine (Atreza, Sal-Tropine);

· belladonna (Donnatal, and others);

· benztropine (Cogentin);

· clidinium (Quarzan);

· clozapine (Clozaril, FazaClo);

· dimenhydrinate (Dramamine);

· methscopolamine (Pamine), scopolamine (Transderm Scop);

· glycopyrrolate (Robinul);

· mepenzolate (Cantil);

· an antibiotic such as neomycin (Mycifradin, Neo Fradin, Neo Tab), kanamycin (Kantrex), or streptomycin, tobramycin (Nebcin, Tobi);

· bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

· bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

· cool medication, allergy medication, or sleeping pills that contain an antihistamine such as diphenhydramine (Tylenol PM) or doxylamine (Unisom);

· heart rhythm medicine such as quinidine (Quin-G), procainamide (Procan, Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;

· irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine);

· medication to treat Alzheimer's dementia, such as donepezil (Aricept), rivastigmine (Exelon), or tacrine (Cognex); or

· a steroid such as betamethasone (Celestone) or dexamethasone (Cortastat, Dexasone, Solurex, DexPak).

• This list is not complete and another drugs may interact with neostigmine. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about neostigmine.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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