Tobramycin (Tobrex, Tobi); Antibacterial, Aminoglycoside; Inj: 10 mg/mL, 40 mg/mL
Ophth soln: 0.3% [5 mL]
Ophth oint: 0.3% [3.5 gm]
Soln for nebulizer: 300 mg/5 mL;
IV/IM:
<5 yrs: 7.5 mg/kg/day q8h
5-10 yrs: 6.0 mg/kg/day q8h.
>10 yrs: 5.0 mg/kg/day q8h
Infuse
IV dose over 30 minutes. Therapeutic peak
serum levels: 4-10 mcg/mL, trough
serum levels: <2 mcg/mL.
Ophth: Instill 1-2 drops into eye(s) q4h, or apply ointment to conjunctival sac bid-tid
The ophthalmic solution can be used in the ears.
Nebulizer (cystic fibrosis patients): >6 yrs: 300 mg
nebulized bid in repeating cycles of 28 days on drug, 28 days off of drug.