GLYBURIDE AND METFORMIN

(GLYE bure ide and met FOR min) Brand: Glucovance

What is the most significant information I must know about glyburide and metformin?

• You must not use this medicine if you are allergic to glyburide or metformin, or if you have kidney malady or are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking glyburide and metformin.

• Till you take this medicine, speak your doctor if you have liver or heart malady, a history of heart onslaught or stroke, or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

• Some people develop lactic acidosis while taking glyburide and metformin. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.

What is glyburide and metformin?

• Glyburide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

• Glyburide and metformin is used to treat type 2 diabetes. This medicine is not for treating type 1 diabetes.

• Glyburide and metformin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking glyburide and metformin?

• You must not use this medicine if you are allergic to glyburide or metformin, if you have kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

· kidney malady; or

· if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking glyburide and metformin.

• Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney malady, congestive heart failure, a severe infection, if you are dehydrated, or if you drink big amounts of alcohol. Older adults may also have a higher risk of developing lactic acidosis. Conversation with your doctor about your individual risk.

• To create certain you can safely take this medicine, speak your doctor if you have any of these another conditions:

· an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

· liver malady; or

· heart malady or a history of heart onslaught or stroke.

· a history of heart onslaught or stroke.

• FDA pregnancy category B. This medication is not expected to harm an unborn child. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medicine around the time of delivery. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether this medication passes into breast milk or if it could harm a nursing child. You must not breast-feed while taking glyburide and metformin.

• Determined oral diabetes medications may magnify your risk of serious heart problems. However, not treating your diabetes can hurt your heart and another organs. Conversation to your doctor about the risks and benefits of treating your diabetes with glyburide and metformin.

How must I take glyburide and metformin?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results.

• Take glyburide and metformin with meals. Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office. Visit your doctor regularly.

• Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating.

• Hold a source of sugar accessible in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.

• Check your blood sugar carefully during a time of stress or diseases, if you travel, exercice more than normal, drink alcohol, or skip meals. These things can affect your glucose levels and your doze needs may also change.

• Ask your doctor how to adjust your doze if needed. Do not change your medicine doze or schedule without your doctor's advice.

• If you need surgery, speak the surgeon onward of time that you are using glyburide and metformin. You may need to stop using the medication for a short time.

• This medication is only part of a complete program of treatment that also includes diet, exercice, and weight control.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember (be certain to take the medication with food). Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. A glyburide and metformin overdose can reason life-threatening hypoglycemia.

• Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

• Overdose may also reason lactic acidosis. Get abnormal medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart course, cool feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

What must I avoid while taking glyburide and metformin?

• Avoid drinking alcohol. It can lower your blood sugar and may magnify the risk of lactic acidosis while you are taking this medicine.

What are the possible side effects of glyburide and metformin?

• This medicine may reason lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get abnormal medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using this medication and call your doctor at once if you have a serious side effect such as:

· pale or yellowed skin, dark colored urine, fever, confusion or weakness; or

· nausea, upper stomach pain, itching, loss of appetite, clay-colored stools, jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· sneezing, runny nose, cough or another signs of a cold;

· headache, mild dizziness; or

· mild dizziness; or

· mild nausea or vomiting, diarrhea, upset stomach.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect glyburide and metformin?

• Speak your doctor about all another medications you use, especially:

· cimetidine (Tagamet) or ranitidine (Zantac);

· morphine (MS Contin, Kadian, Oramorph);

· quinine (Qualaquin);

· an antibiotic such as ciprofloxacin (Cipro), trimethoprim (Proloprim, Primsol, Cotrim), or vancomycin (Vancocin, Lyphocin); or

· heart or blood pressure medicines such as amiloride (Midamor), digoxin (Lanoxin), furosemide (Lasix), nifedipine (Adalat, Procardia), procainamide (Pronestyl), quinidine (Quin-G), or triamterene (Dyrenium).

• You may be more likely to have hyperglycemia (high blood sugar) if you take glyburide and metformin with another drugs that can raise blood sugar, such as:

· isoniazid;

· diuretics (water pills) or blood pressure medicine;

· steroids (prednisone and others);

· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);

· phenothiazines (Compazine and others);

· thyroid medication (Synthroid and others);

· birth control pills and another hormones;

· seizure medicines (Dilantin and others);

· diet pills, medicines to treat asthma, colds or allergies; or

· heart or blood pressure medicine such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.

• You may be more likely to have hypoglycemia (low blood sugar) if you take glyburide and metformin with:

· exenatide (Byetta);

· probenecid (Benemid).

· some nonsteroidal anti-inflammatory drugs (NSAIDs);

· aspirin or another salicylates (including Pepto-Bismol);

· a blood thinner (warfarin, Coumadin, and others);

· sulfa drugs Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others);

· a monoamine oxidase inhibitor (MAOI);

· beta-blockers (Toprol, Inderal, and others); or

· another oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).

• These lists are not complete and there are much another medicines that can magnify or decrease the effects of glyburide and metformin on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about glyburide and metformin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

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