CONJUGATED ESTROGENS (VAGINAL)

(KON joo merry ted ES troe jenz) Brand: Premarin Vaginal

What is the most significant information I must know about vaginal conjugated estrogens?

• Vaginal conjugated estrogens can harm an unborn child or reason birth defects. Do not use if you are pregnant.

• You must not use this medicine if you have any of the next conditions: a history of heart onslaught, stroke, or blood clot (especially in your lung or your lower body), liver malady, emergency vaginal bleeding, or a hormone-related cancer such as breast or uterine cancer.

• Long-term treatment with conjugated estrogens may magnify your risk of breast cancer, heart onslaught, or stroke. Conversation with your doctor about your individual risks till using vaginal conjugated estrogens long term, especially if you smoke or are overweight. Your doctor must check your progress on a regular basis (every 3 to 6 months) to determine whether you must continue this treatment.

• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using vaginal conjugated estrogens.

• Vaginal conjugated estrogens must not be used to prevent heart malady or dementia, because this medicine may actually magnify your risk of developing these conditions.

What are vaginal conjugated estrogens?

• Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for much processes in the body.

• Vaginal conjugated estrogens are a mixture of estrogen hormones used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

• Vaginal conjugated estrogens must not be used to prevent heart malady or dementia, because this medicine may actually magnify your risk of developing these conditions.

• Vaginal conjugated estrogens may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till using vaginal conjugated estrogens?

• You must not use vaginal conjugated estrogens if you are pregnant, or if you have:

· a history of heart onslaught, stroke, or blood clot (especially in your lung or your lower body);

· emergency vaginal bleeding that a doctor has not checked;

· liver malady; or

· any type of breast, uterine, or hormone-dependent cancer.

• To create certain you can safely use vaginal conjugated estrogens, speak your doctor if you have any of these another conditions:

· tall blood pressure, heart malady, or circulation problems;

· a private or family history of stroke;

· endometriosis;

· liver or kidney disease;

· asthma;

· epilepsy or another seizure disorder;

· migraines;

· diabetes;

· underactive thyroid;

· tall cholesterol or triglycerides;

· tall or low levels of calcium in your blood;

· porphyria;

· systemic lupus erythematosus (SLE); or

· gallbladder disease.

• Conjugated estrogens magnify your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using vaginal conjugated estrogens may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using vaginal conjugated estrogens.

• FDA pregnancy category X. This medicine can harm an unborn child or reason birth defects. Do not use vaginal conjugated estrogens if you are pregnant. Speak your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine. You must know that conjugated estrogens vaginal cream can weaken the latex of a condom, diaphragm, or cervical cap. Conversation to your doctor about the excellent contraceptive methods to use.

• Conjugated estrogens can pass into breast milk and may harm a nursing child. This medicine may also slow breast milk manufacture. Do not use if you are breast-feeding a baby.

• Do not use this medicine in anyone under 18 years old without the advice of a doctor.

How must I use vaginal conjugated estrogens?

• Use exactly as predesigned by your doctor. Do not use in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Vaginal conjugated estrogens are generally predesigned for only a short time and are most often used in a cycle, such as 3 weeks on followed by 1 week off. Some conditions require daily use and others require use only twice a week during the treatment period. Follow the directions on your prescription label.

• To apply this medicine, use only the vaginal applicator provided. After every use, take the applicator separately and clean it with mild soap and warm water. Do not use hot or boiling water.

• Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using vaginal conjugated estrogens.

• If you need surgery or medical trials or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you must know that you are using vaginal conjugated estrogens.

• This medicine can affect the results of determined medical trials. Speak any doctor who treats you that you are using vaginal conjugated estrogens.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Use the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not use extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, or vaginal bleeding.

What must I avoid while using vaginal conjugated estrogens?

• Do not smoke while using this medicine. Smoking can magnify your risk of blood clots, stroke, or heart onslaught caused by vaginal conjugated estrogens.

What are the possible side effects of vaginal conjugated estrogens?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using vaginal conjugated estrogens and call your doctor at once if you have a serious side effect such as:

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling;

· sudden numbness or weakness, especially on one side of the body;

· sudden severe headache, confusion, problems with vision, speech, or balance;

· pain, swelling, warmth, or redness in one or both legs;

· emergency vaginal bleeding;

· migraine headache;

· pain, swelling, or tenderness in your stomach;

· confusion, problems with memory or concentration;

· jaundice (yellowing of the skin or eyes);

· swelling in your hands, ankles, or foots; or

· a breast lump.

• Smaller serious side effects may include:

· mild nausea, vomiting, bloating, stomach cramps;

· breast pain, tenderness, or swelling;

· freckles or darkening of facial skin;

· heighten hair growth, loss of scalp hair;

· changes in weight or appetite;

· problems with contact lenses;

· vaginal itching or discharge;

· changes in your menstrual periods, decreased sex drive; or

· headache, nervousness, dizziness, weary feeling.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect vaginal conjugated estrogens?

• Speak your doctor about all another medicines you use, especially:

· a blood thinner such as warfarin (Coumadin, Jantoven);

· a thyroid medicine such as levothyroxine (Synthroid, Levoxyl, Levothroid and others);

· insulin or diabetes medication taken by mouth;

· rifampin (Rifadin, Rifater, Rifamate, Rimactane);

· ketoconazole (Nizoral) or itraconazole (Sporanox);

· seizure medicines such as phenytoin (Dilantin), carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or primidone (Mysoline);

· a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

· antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

• This list is not complete and there may be another drugs that can interact with vaginal conjugated estrogens. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about vaginal conjugated estrogens.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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