PHENYLEPHRINE AND PROMETHAZINE

(fen ill EFF rin and pro MEH thah zeen) Brand: Phenergan VC, Promethazine VC Plain

What is the most significant information I must know about phenylephrine and promethazine?

• Use caution when driving, operating machinery, or performing another hazardous activities. Phenylephrine and promethazine may reason dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

• Use alcohol cautiously. Alcohol may magnify drowsiness and dizziness while taking phenylephrine and promethazine.

What is phenylephrine and promethazine?

• Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the sinuses and nose to decrease congestion.

• Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body.

• Phenylephrine and promethazine is used to treat symptoms such as itching, runny nose; sneezing; and congestion due to allergies or the general cold.

• Phenylephrine and promethazine may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking phenylephrine and promethazine?

• Do not take phenylephrine and promethazine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), or selegiline (Eldepryl) in the recent 14 days. A dangerous drug interaction could occur, leading to serious side effects.

• Till taking phenylephrine and promethazine, speak your doctor if you have

· epilepsy or a seizure disorder;

· been diagnosed with sleep apnea (periods of not breathing during sleep);

· thyroid problems;

· diabetes;

· glaucoma;

· an ulcer or an obstruction in the stomach;

· bladder problems or difficulty urinating;

· an enlarged prostate;

· tall blood pressure, irregular heartbeats, or heart disease;

· kidney problems; or

· liver problems.

• You may not be able to take phenylephrine and promethazine, or you may require a dosage adjustment or particular monitoring during treatment if you have any of the conditions listed above.

• Phenylephrine and promethazine is in the FDA pregnancy category C. This means that it is not known whether phenylephrine and promethazine will be deleterious to an unborn child. Do not take phenylephrine and promethazine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

• It is not known whether phenylephrine and promethazine passes into breast milk. Do not take phenylephrine and promethazine without first talking to your doctor if you are breast-feeding a baby.

• If you are over 60 years of age, you may be more likely to experience side effects from phenylephrine and promethazine. Your doctor may prescribe a lower doze of this medication.

How must I take phenylephrine and promethazine?

• Take phenylephrine and promethazine exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain the instructions to you.

• Phenylephrine and promethazine can be taken with or without food.

• To ensure that you get a correct doze, measure the liquid form of phenylephrine and promethazine with a particular dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

• Store phenylephrine and promethazine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. However, if it is nearly time for the following doze, skip the missed doze and take only the following regularly scheduled doze. Do not take a double doze of this medicine unless otherwise directed by your doctor.

What happens if I overdose?

• Search abnormal medical attention if an overdose is suspected.

• Symptoms of a phenylephrine and promethazine overdose include severe drowsiness, dizziness, headache, seizures, dry mouth, big pupils, flushing, nausea, vomiting, difficulty breathing, and unconsciousness.

What must I avoid while taking phenylephrine and promethazine?

• Use alcohol cautiously. Alcohol may magnify drowsiness and dizziness while taking phenylephrine and promethazine.

• Avoid prolonged exposure to sunlight. Phenylephrine and promethazine may magnify the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

• Do not take another over-the-counter cough, cool, allergy, diet, pain, fever, or sleep medicines while taking phenylephrine and promethazine without first talking to your doctor or pharmacist. Another medications may also contain phenylephrine, promethazine or another similar drugs, and you may accidentally take too many, which could be harmful.

What are the possible side effects of phenylephrine and promethazine?

• If you experience any of the next serious side effects, stop taking phenylephrine and promethazine and search abnormal medical attention or contact your doctor immediately:

· an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or person; or hives); or

· uncontrollable movements of the eyes, lips, tongue, person, arms, or legs.

• Another, smaller serious side effects may be more likely to occur. Continue to take phenylephrine and promethazine and conversation to your doctor if you experience

· dizziness, drowsiness, sleepiness, or confusion;

· restlessness or irritability;

· blurred vision or a dry mouth;

· nausea or vomiting; or

· heighten skin sensitivity to sunlight.

• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect phenylephrine and promethazine?

• Phenylephrine and promethazine may magnify the effects of another drugs that reason drowsiness, including antidepressants, alcohol, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Speak your doctor about all medicines that you are taking, and do not take any medication unless your doctor approves.

• Drugs another than those listed here may also interact with phenylephrine and promethazine. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has more information about phenylephrine and promethazine written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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