LINAGLIPTIN AND METFORMIN

(LIN a GLIP tin and met FOR min) Brand: Jentadueto

Buy cheap Linagliptin and metformin

What is the most significant information I must know about linagliptin and metformin?

• Do not use this medicine if you are allergic to linagliptin (Onglyza) or metformin (Actoplus Met, Avandamet, Fortamet, Glucophage, Riomet), if you have kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• Till you take linagliptin and metformin, speak your doctor if you have liver malady, a serious infection, heart malady, a history of pancreatitis, if you have recently had a heart onslaught, or if you are over 80 years old and have not recently had your kidney function checked.

If you need to have surgery or any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking linagliptin and metformin.

• Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or weary.

What is linagliptin and metformin?

Linagliptin and metformin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) manufacture in the liver and decreasing absorption of glucose by the intestines. Linagliptin works by regulating the levels of insulin your body produces after eating.

• The combination of linagliptin and metformin is used to treat type 2 diabetes. This medicine is not for treating type 1 diabetes.

Linagliptin and metformin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking linagliptin and metformin?

• Do not use this medicine if you are allergic to metformin (Actoplus Met, Avandamet, Fortamet, Glucophage, Riomet) or linagliptin (Onglyza), if you have kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you need to have surgery or any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking linagliptin and metformin. Be certain your caregivers know onward of time that you are using this medication.

• To create certain you can safely take linagliptin and metformin, speak your doctor if you have any of these another conditions:

· liver malady;

· heart disease;

· a serious infection called sepsis;

· a history of pancreatitis;

· if you have recently had a heart onslaught; or

· if you are over 80 years old and have not recently had your kidney function checked.

• Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney malady, congestive heart failure, a severe infection, if you are dehydrated, or if you drink big amounts of alcohol. Conversation with your doctor about your individual risk.

• FDA pregnancy category B. Linagliptin and metformin is not expected to harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether linagliptin and metformin passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using this medication.

How must I take linagliptin and metformin?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label. Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office.

• Take linagliptin and metformin twice daily with meals, unless your doctor tells you otherwise.

• Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, famine, weakness, sweating, tremor, irritability, or trouble concentrating.

• Always hold a source of sugar accessible in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and can't ate or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon abnormal injection kit and speak you how to give the injection.

• Check your blood sugar carefully during a time of stress or diseases, if you travel, exercice more than normal, drink alcohol, or skip meals. These things can affect your glucose levels and your doze needs may also change.

• Ask your doctor how to adjust your linagliptin and metformin doze if needed. Do not change your medicine doze or schedule without your doctor's advice.

• Your doctor may have you take extra vitamin B12 while you are taking metformin. Take only the amount of vitamin B12 that your doctor has prescribed.

Linagliptin and metformin is only part of a complete program of treatment that may also include diet, exercice, weight control, and testing your blood sugar. Follow your diet, medicine, and exercice routines very closely. Changing any of these factors can affect your blood sugar levels.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember (be certain to take the medication with food). Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

• An overdose of metformin may reason lactic acidosis. Get abnormal medical help if you have: weakness, increasing sleepiness, slow heart course, cool feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

What must I avoid while taking linagliptin and metformin?

• Avoid drinking alcohol. It lowers blood sugar and may magnify your risk of lactic acidosis.

What are the possible side effects of linagliptin and metformin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• This medicine may reason lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get abnormal medical help if you have even mild symptoms of lactic acidosis, such as:

· muscle pain or weakness;

· numb or cool feeling in your arms and legs;

· trouble breathing;

· feeling dizzy, light-headed, weary, or very weak;

· stomach pain, nausea with vomiting; or

· slow or uneven heart rate.

• Stop using this medication and call your doctor at once if you have a serious side effect such as:

· swelling, rapid weight gain; or

· severe pain in your upper stomach spreading to your back, nausea and vomiting, and quick heart rate.

• Smaller serious side effects may include:

· cough, sore throat

· sinus pain, stuffy nose;

· upset stomach, diarrhea; or

· weight gain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect linagliptin and metformin?

• Speak your doctor about all another medicines you use, especially:

· acetazolamide (Diamox);

· bosentan (Tracleer);

· cimetidine (Tagamet);

· dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

· digoxin (Lanoxin, Lanoxicaps);

· isoniazid (for treating tuberculosis);

· morphine (Kadian, MS Contin, Oramorph);

· rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

· St. John's wort;

· topiramate (Topamax);

· vancomycin (Vancocin);

· zonisamide (Zonegran);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

· heart rhythm medicine such as procainamide (Procan, Pronestyl, Procanbid) or quinidine (Quin-G);

· HIV/AIDS medicine such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);

· medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);

· seizure medicine such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline); or

· trimethoprim (Primsol, Proloprim, Bactrim, Septra, Sulfatrim, SMX-TMP, and others).

• You may be more likely to have hyperglycemia (high blood sugar) if you take linagliptin and metformin with another drugs that can raise blood sugar, such as:

· heart or blood pressure medications;

· diuretics (water pills);

· steroids (prednisone and others);

· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);

· phenothiazines (Compazine and others);

· thyroid medication (Synthroid and others);

· birth control pills and another hormones;

· seizure medicines (Dilantin and others); or

· diet pills or medicines to treat asthma, colds or allergies.

These lists are not complete and there are much another medicines that can magnify or decrease the effects of linagliptin and metformin on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about linagliptin and metformin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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