ABIRATERONE

(A bir A te rone) Brand: Zytiga

What is the most significant information I must know about abiraterone?

• You must not use this medicine if you are allergic to abiraterone, if you have severe liver malady, or if you are pregnant.

• Till you take abiraterone, speak your doctor if you have liver malady, low levels of potassium in your blood, any type of infection, tall blood pressure, congestive heart failure, or a history of heart malady, fluid retention, last heart onslaught, or problems with your adrenal gland or pituitary gland.

• Although abiraterone is not for use by women, this medication can harm an unborn child or reason birth defects. Abiraterone tablets must not be handled by a woman who is pregnant or who may become pregnant.

• While you are taking abiraterone and for at least 1 week after your treatment ends: Use a condom to prevent transfer of this medicine to your sexual partner if she is pregnant. Use a condom plus other form of effective birth control if your sexual partner could become pregnant.

• Abiraterone should be taken on an empty stomach.

What is abiraterone?

• Abiraterone works in the body by preventing the actions of androgens (male hormones).

• Abiraterone is used together with prednisone to treat prostate cancer that has spread to another parts of the body.

• Abiraterone may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking abiraterone?

• You must not use this medicine if you are allergic to abiraterone, if you have severe liver malady, or if you are pregnant.

• To create certain abiraterone is safety for you, speak your doctor if you have:

· liver disease;

· heart malady, tall blood pressure;

· low levels of potassium in your blood;

· a history of heart malady, fluid retention, or last heart onslaught; or

· a history of problems with your adrenal gland or pituitary gland.

• While you are taking abiraterone and for at least 1 week after your treatment ends:

· If your sexual partner is pregnant--Use a condom to prevent transfer of this medicine to her.

· If your sexual partner could become pregnant--Use a condom plus other form of effective birth control to prevent pregnancy.

• FDA pregnancy category X. Although abiraterone is not for use by women, this medicine can harm an unborn child or reason birth defects. Abiraterone tablets must not be handled by a woman who is pregnant or who may become pregnant. If this can't be avoided, the woman must wear latex gloves.

• It is not known whether abiraterone passes into breast milk or if it could harm a nursing child. Abiraterone must not be used by a woman who is breast-feeding a baby.

How must I take abiraterone?

• Follow all directions on your prescription label. Abiraterone is generally taken once for day while also taking prednisone two times for day. Do not take this medication in larger or less amounts or for longer than recommended.

• Your prednisone dosage needs may change if you have surgery, are ill, or are under stress. Do not change your medicine doze or schedule without your doctor's advice.

• Take this medication with a full glass of water. Swallow the abiraterone tablet whole.

• Take abiraterone on an empty stomach. Do not ate anything for at least 2 hours till you take abiraterone and for at least 1 hour after you have taken the medicine.

• Your blood pressure will need to be checked often, and you may need frequent blood trials at your doctor's office.

• You must not stop using abiraterone or prednisone suddenly. Follow your doctor's instructions about tapering your prednisone dose.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Skip the missed doze and take the medication the next day on an empty stomach (no food for at least 2 hours till or 1 hour after you take abiraterone). Do not take extra medication to create up the missed dose.

• Call your doctor for instructions if you miss more than one doze of abiraterone.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking abiraterone?

• Avoid eating for at least 2 hours till you take abiraterone and for at least 1 hour after your doze. Food can magnify the amount of abiraterone your body absorbs.

What are the possible side effects of abiraterone?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using abiraterone and call your doctor at once if you have:

· swelling in your ankles or foots, pain in your legs;

· rapid heartbeats, feeling short of breath (even with mild exertion);

· low potassium (confusion, uneven heart course, extreme thirst, heighten urination, leg discomfort, muscle weakness or limp feeling);

· pale skin, light bruising, feeling like you might pass out;

· upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);

· pain or burning when you urinate;

· tall blood sugar (increased thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

· worsening dizziness, weakness, or weary feeling;

· nausea, vomiting, ongoing diarrhea; or

· dangerously tall blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

• General side effects may include:

· swelling or discomfort in your joints;

· mild diarrhea;

· cough; or

· sweating, feeling very hot.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect abiraterone?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with abiraterone, especially:

· cough or cool medication that contains dextromethorphan;

· the heart rhythm medicines flecainide or propafenone;

· prostate or breast cancer medications such as leuprolide, buserelin, histrelin, or goserelin;

· thioridazine;

· an antidepressant--amitriptyline, doxepin, clomipramine, desipramine, imipramine, nortriptyline.

• This list is not complete. Another drugs may interact with abiraterone, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about abiraterone.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.