METHYL AMINOLEVULINATE (TOPICAL)

(METH il a MEE noe LEV ue LIN ate) Brand: Metvixia

What is the most significant information I must know about methyl aminolevulinate?

• You must not use this medicine if you are allergic to methyl aminolevulinate, porphyrins, peanuts or almonds, or if your skin is especially sensitive to light.

• Till you are treated with methyl aminolevulinate, speak your doctor about all of your medical conditions. Also speak your doctor about all another medications you use, especially drugs that can create your skin more sensitive to sunlight, such as determined antibiotics, heart or blood pressure medications, diuretics (water pills), sulfa drugs, oral diabetes medications, or NSAID pain or arthritis medicines.

• Methyl aminolevulinate is applied by a healthcare provider in a clinic setting.

• For at least 48 hours after your treatment, avoid exposing treated skin to sunlight, sunlamps, tanning beds, or another bright lights. Sunscreen is not effective satis to protect treated skin from harm caused by bring easy during this time. Wear protective clothing whenever you are outdoors.

• Call your doctor at once if you have severe stinging, burning, redness, oozing, or swelling of treated skin areas, especially if you have these effects for longer than 3 weeks after treatment.

• It may take different weeks till you announcement improvement in your skin condition. Your doctor will need to check your treated skin 3 months after the end of your recent treatment with methyl aminolevulinate.

• Your skin lesions may need to be treated more than once, and they may come back after treatment. Conversation to your doctor about the number of treatments needed to treat your condition.

What is methyl aminolevulinate?

• Methyl aminolevulinate makes your skin more sensitive to easy. It works by causing a reaction with easy that can destroy determined types of diseased skin cells.

• Methyl aminolevulinate topical (for the skin) is used in combination with red easy therapy to treat a skin condition called actinic keratosis of the person and scalp.

• Methyl aminolevulinate may also be used for another purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking methyl aminolevulinate?

• You must not use this medicine if you are allergic to methyl aminolevulinate, or if you have:

· an allergy to peanuts or almonds;

· an allergy to porphyrins; or

· if your skin is especially sensitive to light.

• Till you are treated with methyl aminolevulinate, speak your doctor about all of your medical conditions.

• FDA pregnancy category C. It is not known whether methyl aminolevulinate is deleterious to an unborn child. Till taking this medicine, speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether methyl aminolevulinate passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How is methyl aminolevulinate used?

• Methyl aminolevulinate topical is a cream that is applied to actinic keratosis skin lesions prior to red easy treatment. Your doctor, nurse, or another healthcare provider will prepare your skin and apply this medicine in a clinic setting.

• Prior to application of methyl aminolevulinate, your skin lesions will be gently scraped to remove any scales or crusting. After the medicine is applied, your caregiver will cover the treatment area with a bandage. You will need to leave this bandage in seat for 3 hours.

• During this 3-hour period, avoid exposure to cool temperatures and sunlight or bright indoor lights. Wear a wide-brimmed hat if you should be outdoors during this time.

• After your bandaging is removed, any excess medicine will be removed with a saline solution. You will then be ready to receive the easy treatment.

• You will be given eye-wear to protect your eyes during red easy treatment.

• You may feel a slight stinging or burning during easy therapy. Speak your caregivers if you have any type of severe discomfort.

• Methyl aminolevulinate and red easy therapy is generally given in two sessions one week separately. Your treatment schedule may be various. Follow your doctor's instructions.

• Your skin lesions may need to be treated more than once, and they may come back after treatment. Conversation to your doctor about the number of treatments needed to treat your condition.

What happens if I miss a dose?

• Since methyl aminolevulinate is applied only when needed prior to red easy therapy, you will not be on a dosing schedule.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Symptoms of a methyl aminolevulinate overdose are not known.

What must I avoid while taking methyl aminolevulinate?

• Speak your caregivers right away if any of this medicine gets into your eyes, mouth, or nose.

• Avoid touching the treated skin areas after methyl aminolevulinate cream has been applied to them. Particular gloves should be worn by the healthcare provider while applying this medicine, and you must not let your own fingers to come into contact with the cream on your skin.

• Even if you do not receive the easy therapy portion of your treatment, you should still protect your skin from easy for 48 hours after the cream was applied.

What are the possible side effects of methyl aminolevulinate?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have severe stinging, burning, redness, oozing, or swelling of treated skin areas, especially if you have these effects for longer than 3 weeks after treatment.

• Smaller serious side effects may include:

· mild skin redness, warmth, burning, or swelling;

· puffy eyes;

· slight pain; or

· itching, peeling, scabs or crusting of treated skin.

• This is not a complete list of side effects and others may occur. Speak your doctor about any unusual or bothersome side effect.

What another drugs will affect methyl aminolevulinate?

• Speak your doctor about all another medications you use, especially drugs that can create your skin more sensitive to sunlight, such as:

· amiodarone (Cordarone, Pacerone);

· diabetes medications you take by mouth;

· diltiazem (Tiazac, Cartia, Cardizem);

· furosemide (Lasix);

· porfimer (Photofrin);

· quinidine (Quinaglute, Quinidex, Quin-Release);

· tacrolimus (Prograf);

· verteporfin (Visudyne);

· an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);

· an antibiotic such as ciprofloxacin (Cipro), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), levofloxacin (Levaquin), ofloxacin (Floxin), norfloxacin (Noroxin), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);

· a diuretic (water pill) such as hydrochlorothiazide (HCTZ), contained in Aldoril, Atacand, Capozide, HydroDiuril, Hyzaar, Lopressor, Lotensin, Moduretic, Monopril, Tekturna, Teveten, Vaseretic, Zestoretic, Ziac, and others;

· an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others; or

· a sulfa drug (such as Bactrim, Septra, SMX-TMP, and others).

• This list is not complete and there may be another drugs that can interact with methyl aminolevulinate. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about methyl aminolevulinate.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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