HYDRALAZINE AND ISOSORBIDE DINITRATE

(hi dral LA zeen and I so zor bi da din eye treyt) Brand: BiDil

What is the most significant information I must know about hydralazine and isosorbide dinitrate?

• You may develop a headache because of this medication, but do not stop taking it. Take aspirin or acetaminophen to treat the headache. Ask your doctor which is excellent for you. This side effect generally goes away with continued hydralazine and isosorbide dinitrate treatment.

• Do not stop taking hydralazine and isosorbide dinitrate suddenly. Conversation to your doctor till you stop taking the drug completely.

• Do not drink alcohol while taking this medication.

• Use caution when driving, operating machinery, or performing another hazardous activities. Hydralazine and isosorbide dinitrate may reason dizziness. If you experience dizziness, avoid these activities.

What is hydralazine and isosorbide dinitrate?

• Hydralazine is a vasodilator. It relaxes (widens) veins and arteries, which makes it easier for your heart to pump.

• Isosorbide dinitrate is in a class of drugs called nitrates. Isosorbide dinitrate dilates (widens or relaxes) blood vessels (arteries and veins). When blood vessels are dilated, it is easier for the heart to exhaust. Also, more blood, which is wealthy in oxygen, can flow to the heart.

• Hydralazine and isosorbide dinitrate is used to treat heart failure.

• Hydralazine and isosorbide dinitrate may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking hydralazine and isosorbide dinitrate?

• Till taking this medicine, speak your doctor if you

· have low blood pressure;

· have had a stroke, a transient ischemic onslaught (TIA, or mini-stroke), or a serious head injury;

· have anemia;

· have an allergy to nitrates;

· have closed-angle glaucoma;

· suffer from migraines;

· have systemic lupus erythematosus;

· have tall levels of cholesterol or triglycerides (types of fat) in your blood;

· have pulmonary hypertension;

· have kidney malady; or

· have liver disease.

• You may not be able to take hydralazine and isosorbide dinitrate, or you may require a dosage adjustment or particular monitoring during therapy.

• Hydralazine and isosorbide dinitrate is in the FDA pregnancy category C. This means that it is not known whether hydralazine and isosorbide dinitrate will harm an unborn child. Do not take this medicine without first talking to your doctor if you are pregnant.

• It is also not known whether hydralazine or isosorbide dinitrate pass into breast milk. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

• If you are over 60 years of age, you may be more likely to experience dizziness from hydralazine. You may require a lower doze or particular monitoring during therapy.

How must I take hydralazine and isosorbide dinitrate?

• Take hydralazine and isosorbide dinitrate exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

• Take every doze with a full glass of water.

• Do not stop taking hydralazine and isosorbide dinitrate suddenly. Conversation to your doctor till you stop taking the drug completely.

• Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If your following regularly scheduled doze is within 2 hours, skip the doze you missed and take only the following doze. Do Not take a double doze of this medication.

What happens if I overdose?

• Search abnormal medical attention.

• Symptoms of an hydralazine and isosorbide dinitrate overdose include a severe throbbing headache, difficult or slow breathing, muscle cramps, nausea, vomiting, diarrhea, fever, dizziness, fainting, an irregular or slow heart beat, changes in vision, confusion, flushing, and seizures.

What must I avoid while taking hydralazine and isosorbide dinitrate?

• Avoid alcohol. Alcohol also widens your blood vessels, and it can reason very low blood pressure, dizziness, and drowsiness. If you consume alcohol, you could endanger yourself or others.

• Do not stop taking hydralazine and isosorbide dinitrate suddenly. Conversation to your doctor till you stop taking the drug completely.

What are the possible side effects of hydralazine and isosorbide dinitrate?

• If you experience any of the next serious side effects, stop taking hydralazine and isosorbide dinitrate and search abnormal medical attention:

· an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or person; or hives);

· blurred vision and dry mouth;

· irregular heartbeat; or

· blood in your urine or stools;

· numbness, tingling, pain, or weakness of your arms or legs;

· fainting.

• Another, smaller serious side effects may be more likely to occur. If you experience any of the next side effects, continue to take isosorbide and conversation to your doctor:

· headache or dizziness;

· flushing (redness of the person, neck and chest);

· nausea or vomiting;

· quick heartbeat;

· swollen ankles; or

· weakness.

• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect hydralazine and isosorbide dinitrate?

• Do not use sildenafil (Viagra, Revatio), vardenafil (Levitra), or tadalafil (Cialis) while taking hydralazine and isosorbide dinitrate. The combination could reason severe or life-threatening low blood pressure.

• Till taking hydralazine and isosorbide dinitrate, speak your doctor if you are taking any of the next medicines:

· dihydroergotamine (D.H.E. 45); or

· any another heart medicines, especially those used to treat tall blood pressure or irregular heartbeats.

• You may require a dosage adjustment or particular monitoring during your treatment if you are taking any of the medicines listed above.

• Drugs another than those listed here may also interact with hydralazine and isosorbide dinitrate or affect your condition. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about hydralazine and isosorbide dinitrate written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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