ENZALUTAMIDE

(ENZ a LOOT a mide) Brand: Xtandi

What is the most significant information I must know about enzalutamide?

• Although not for use by women, enzalutamide can reason birth defects if the mother or the father is taking this medicine. Use a condom and one another form of birth control to prevent pregnancy during your treatment, and for at least 3 months after your treatment ends.

• Enzalutamide can magnify your risk of having a seizure. Speak your doctor if you have a history of seizures, or if you have recently had a head injury, stroke, or brain tumor. Also speak your doctor about all medicines you use.

• Enzalutamide may reason side effects on your spinal cord. Stop taking this medication and call your doctor at once if you have severe low back pain, trouble walking or standing up, pain or weakness in your lower body, severe and worsening numbness or tingling, or sudden loss of bladder or bowel control.

What is enzalutamide?

• Enzalutamide is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones).

• Enzalutamide is used to treat prostate cancer.

• Enzalutamide may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking enzalutamide?

• Enzalutamide can magnify your risk of having a seizure. To create certain this medication is safety for you, speak your doctor if you have:

· a history of seizures or epilepsy; or

· a last head injury, stroke, or brain tumor (in the past 12 months).

• FDA pregnancy category X. Although not for use by women, enzalutamide can reason birth defects if the mother or the father is taking this medication. Do not use enzalutamide if you are pregnant.

• If you are taking enzalutamide and your sexual partner could become pregnant, use a condom and one another form of birth control to prevent pregnancy during treatment. Hold using these birth control methods for at least 3 months after your treatment ends. Speak your doctor at once if a pregnancy occurs while either parent is being treated with enzalutamide.

• Although this medication is not for use by women, it is not known whether enzalutamide passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

How must I take enzalutamide?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• You may take enzalutamide with or without food. Take the medication at the same time every day.

• Do not crush, interrupt, or dissolve a enzalutamide capsule. Swallow it whole.

• Prostate cancer is sometimes treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medicine schedule without your doctor's advice.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze if you remember it later in the day. Skip the missed doze if it is nearly time for your following day's doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking enzalutamide?

• This medicine can create you dizzy, and may reason you to have a seizure or suddenly become unconscious. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of enzalutamide?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop using enzalutamide and call your doctor at once if you have:

· seizure (black-out or convulsions);

· severe low back pain, trouble walking or standing up;

· pain or weakness in your lower body, severe and worsening numbness or tingly feeling;

· sudden loss of bladder or bowel control;

· fever, cough with yellow or green mucus, stabbing chest pain, wheezing, feeling short of breath;

· red or pink urine; or

· heighten blood pressure (severe headache, blurred vision, buzzing in your ears, confusion, chest pain, uneven heartbeats).

• General side effects may include:

· anxiety, dizziness, headache, sleep problems (insomnia);

· feeling weak or tired;

· back pain, joint or muscle pain, muscle weakness;

· flushing (warmth, redness, hot feeling);

· numbness, burning pain, or prickly feeling under your skin;

· swelling in your hands or feet;

· diarrhea; or

· cool symptoms such as stuffy nose, sneezing, sore throat.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect enzalutamide?

• Enzalutamide can magnify your risk of having a seizure. This effect may be more likely if you also use determined another medicines that magnify seizure risk. Speak your doctor if you are using an antibiotic, an antidepressant, asthma medicine (bronchodilator), birth control pills or hormone replacement, insulin or oral diabetes medication, a steroid, or medication to treat mental illness.

• Much drugs can interact with enzalutamide. Not all possible interactions are listed here. Speak your doctor about all your medications and any you start or stop using during treatment with enzalutamide, especially:

· gemfibrozil;

· quinidine;

· alfentanil, fentanyl;

· dihydroergotamine, ergotamine;

· a blood thinner such as warfarin, Coumadin;

· herbal products--echinacea, St. John's wort;

· HIV/AIDS medication--efavirenz, etravirine, nevirapine, ritonavir;

· medication for narcolepsy--armodafinil, modafinil;

· medication to prevent organ transplant rejection--cyclosporine, sirolimus, tacrolimus;

· seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone, rufinamide; or

· tuberculosis medication--rifampin.

• This list is not complete and much another drugs can interact with enzalutamide. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about enzalutamide.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.