SULFAMETHOXAZOLE AND TRIMETHOPRIM

(SUL fa meth OX a zole and trye METH oh prim) Brand: Bactrim, Bactrim DS, Septra, Septra DS, SMZ-TMP DS, Sulfatrim Pediatric

What is the most significant information I must know about sulfamethoxazole and trimethoprim?

• You must not use this medicine if you are allergic to sulfamethoxazole or trimethoprim, if you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid deficiency.

• Till using this medicine, speak your doctor if you have kidney or liver malady, a folic acid deficiency, asthma or severe allergies, a thyroid mess, HIV or AIDS, porphyria, G6PD deficiency, or if you are malnourished.

• Take this medication for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antibiotics. Sulfamethoxazole and trimethoprim will not treat a viral infection such as the general cool or flu.

• Antibiotic medicines can reason diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medication to stop the diarrhea unless your doctor has told you to.

• Avoid exposure to sunlight or tanning beds. This medicine can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What is sulfamethoxazole and trimethoprim?

• Sulfamethoxazole and trimethoprim are both antibiotics that treat various types of infection caused by bacteria.

• The combination of sulfamethoxazole and trimethoprim is used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.

• Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking sulfamethoxazole and trimethoprim?

• To create certain this medicine is safety for you, speak your doctor if you have any of these another conditions:

· kidney or liver disease;

· a folic acid deficiency;

· asthma or severe allergies;

· a thyroid disorder;

· HIV or AIDS;

· porphyria (a genetic enzyme mess that causes symptoms affecting the skin or nervous system);

· a glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency); or

· if you are malnourished.

• FDA pregnancy category C. It is not known whether sulfamethoxazole and trimethoprim will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Sulfamethoxazole and trimethoprim can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Do not give this medicine to a baby younger than 2 months old.

• Older adults may be more likely to have side effects from this medicine.

How must I take sulfamethoxazole and trimethoprim?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Measure liquid medication with a particular dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

• Drink plenty of fluids to prevent kidney stones while you are taking trimethoprim and sulfamethoxazole.

• This medicine can reason unusual results with determined medical trials. Speak any doctor who treats you that you are using sulfamethoxazole and trimethoprim.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include severe forms of some of the side effects listed in this medicine guide.

What must I avoid while taking sulfamethoxazole and trimethoprim?

• Antibiotic medicines can reason diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking this medicine and call your doctor. Do not use anti-diarrhea medication unless your doctor tells you to.

• Avoid exposure to sunlight or tanning beds. This medicine can create you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of sulfamethoxazole and trimethoprim?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· diarrhea that is watery or bloody;

· fever, chills, swollen glands, body aches, flu symptoms, sores in your mouth and throat;

· new or worsening cough;

· pale skin, feeling light-headed, rapid heart course, trouble concentrating;

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

· severe tingling or numbness, slow heart course, weak pulse, muscle weakness;

· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· urinating smaller than normal or not at all;

· hallucinations, seizure (convulsions);

· low blood sugar (headache, famine, weakness, sweating, confusion, irritability, or feeling jittery);

· the first sign of any skin rash, no matter how mild; or

· severe skin reaction -- fever, sore throat, swelling in your person or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the person or upper body) and causes blistering and peeling.

• Smaller serious side effects may include:

· vomiting;

· painful or swollen tongue;

· dizziness, spinning sensation;

· ringing in your ears; or

· weary feeling, sleep problems (insomnia).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect sulfamethoxazole and trimethoprim?

• Speak your doctor about all another medications you use, especially:

· an antidepressant;

· a blood thinner such as warfarin (Coumadin, Jantoven);

· cyclosporine (Gengraf, Neoral, Sandimmune);

· oral diabetes medication;

· digoxin (Lanoxin, Lanoxicaps);

· a diuretic (water pill);

· indomethacin (Indocin);

· leucovorin, calcium folinate;

· methotrexate (Trexall, Rheumatrex);

· heart or blood pressure medicine such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

· seizure medicine such as phenytoin (Dilantin);

• This list is not complete and another drugs may interact with sulfamethoxazole and trimethoprim. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about sulfamethoxazole and trimethoprim.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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