MISOPROSTOL

(mye so PRAH stole) Brand: Cytotec

What is the most significant information I must know about misoprostol?

• Do not take misoprostol for the prevention of stomach ulcers if you are pregnant or if you might become pregnant during treatment. If you do become pregnant during treatment with misoprostol, stop taking the medicine and contact your doctor immediately. Misoprostol is in the FDA pregnancy category X. This means that misoprostol is known to be deleterious to an unborn child. Misoprostol can reason miscarriage or spontaneous abortion (sometimes incomplete which could lead to dangerous bleeding and require hospitalization and surgery), premature birth, or birth defects. Misoprostol has also been reported to reason uterine rupture (tearing) when given after the eighth week of pregnancy, which can result in severe bleeding, hysterectomy, and/or maternal or fetal death. A pregnancy test with negative results will be required within 2 weeks of starting treatment with misoprostol, and treatment will begin only on the second or third day of a regular menstrual cycle. Also, appropriate contraception will be needed to prevent pregnancy during treatment and for one menstrual cycle next treatment. In some cases, misoprostol may be used under the supervision of a doctor for the induction of labor and delivery or abortion.

• Do not share this medicine with anyone else. Misoprostol has been predesigned for your specific condition, may not be the correct treatment for other face, and would be dangerous if the another face were pregnant.

What is misoprostol?

• Misoprostol reduces stomach acid and replaces protective substances in the stomach that are inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.

• Misoprostol is used to prevent the formation of ulcers in the stomach during treatment with aspirin or an NSAID such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox, Naprelan), oxaprozin (Daypro), indomethacin (Indocin), diclofenac (Voltaren, Cataflam), etodolac (Lodine), piroxicam (Feldene), meloxicam (Mobic), tolmetin (Tolectin), nabumetone (Relafen), and fenoprofen (Nalfon). NSAIDs and aspirin are used to treat pain, fever, arthritis, and inflammatory conditions.

• Misoprostol may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my healthcare provider till taking misoprostol?

• Till taking misoprostol, speak your doctor if you have inflammatory bowel malady, irritable bowel syndrome, or another intestinal problems. You may need a dosage adjustment or particular monitoring during treatment with misoprostol.

• It is not known whether misoprostol passes into breast milk. Do not take misoprostol without first talking to your doctor if you are breast-feeding a baby.

How must I take misoprostol?

• Take misoprostol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

• Take every doze with a full glass of water.

• Misoprostol is generally taken four times a day, with meals and at bedtime. Follow your doctor's instructions.

• Misoprostol may reason mild to temperate diarrhea, stomach cramps, and/or nausea. These problems generally occur during the first little weeks of treatment and stop after about a week. The occurrence of diarrhea may be minimized by taking misoprostol with food. Contact your doctor if these symptoms persist for longer than 8 days or if they are severe.

• Take misoprostol for the full amount of time predesigned by your doctor. Treatment generally continues for as long as aspirin or an NSAID is taken.

• Store misoprostol at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. However, if it is nearly time for the following doze, skip the missed doze and take only the following regularly scheduled doze. Do not take a double doze of this medication.

What happens if I overdose?

• Search abnormal medical attention.

• The symptoms of a misoprostol overdose are not well known but might include stomach upset, stomach pain, diarrhea, drowsiness, tremor, seizures, difficulty breathing, fever, low blood pressure, and an irregular heart beat.

What must I avoid while taking misoprostol?

• The incidence of diarrhea may be reduced by avoiding antacids that contain magnesium. If an antacid is needed, one that contains aluminum or calcium may be a more appropriate choice.

• There are no restrictions on food, beverages, or activities during treatment with misoprostol unless otherwise directed by your doctor.

What are the possible side effects of misoprostol?

• Stop taking misoprostol and search abnormal medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or person; or hives).

• Another, smaller serious side effects may also occur. Continue to take misoprostol and conversation to your doctor if you experience

· vomiting;

· flatulence;

· constipation;

· headache; or

· menstrual cramps, spotting, or heighten or irregular menstruation.

• Side effects another than those listed here may also occur. Conversation to your doctor about any side effect that seems unusual or that is especially bothersome. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect misoprostol?

• The incidence of diarrhea may be reduced by avoiding antacids that contain magnesium. If an antacid is needed, one that contains aluminum or calcium may be a more appropriate choice.

• Drugs another than those listed here may also interact with misoprostol. Conversation to your doctor and pharmacist till taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has more information about misoprostol written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

(13)