(dex ray ZOX ane) Brand: Totect, Zinecard
• You must not receive Totect if you are pregnant. It could harm the unborn child. If possible till you receive Totect, speak your doctor if you are pregnant. It is not known whether Zinecard will harm an unborn child.
• You must not receive this medicine if your chemotherapy does not include doxorubicin or a similar medicine such as daunorubicin (Cerubidine), epirubicin (Ellence), idarubicin (Idamycin), or mitoxantrone (Novantrone).
• Till you receive dexrazoxane, speak your doctor if you have liver or kidney malady, or if you are pregnant or breast-feeding.
• Speak your doctor at once if you have serious side effects such as fever, chills, body aches, flu symptoms, light bruising or bleeding, or sores your mouth or throat.
• In an abnormal situation it may not be possible till you are treated to speak your caregivers about your health conditions or if you are pregnant or breast feeding. Create certain any doctor caring for you afterward knows that you have received Totect.
• Dexrazoxane is used to protect the heart and another tissues from deleterious side effects caused by determined cancer medications.
• The Zinecard brand of dexrazoxane is used in women who are receiving doxorubicin for metastatic breast cancer.
• The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medication escapes from the blood vessels and circulates into tissues in the body. Serious tissue hurt can occur when extravasation happens during injection of determined cancer medications.
• Dexrazoxane may also be used for purposes not listed in this medicine guide.
• You must not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medicine such as:
· daunorubicin (Cerubidine);
· epirubicin (Ellence);
· idarubicin (Idamycin); or
· mitoxantrone (Novantrone);
• If possible till you receive dexrazoxane, speak your doctor if you have:
· liver disease;
· kidney malady; or
· if you are pregnant or breast-feeding.
• Zinecard is rated as FDA pregnancy category C. It is not known whether Zinecard will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• Totect is rated as FDA pregnancy category D. Do not use Totect if you are pregnant. It could harm the unborn child. If possible till you receive Zinecard, speak your doctor if you are pregnant.
• It is not known whether dexrazoxane passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using dexrazoxane.
• In an abnormal situation, it may not be possible till you are treated with Totect to speak your caregivers if you are pregnant or breast feeding. Create certain any doctor caring for your pregnancy or your child knows you have received this medication.
• Dexrazoxane is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.
• Totect is generally started within 6 hours after extravasation, and continued once daily for 3 days.
• Zinecard is generally started 30 minutes till you receive your doxorubicin injection.
• Dexrazoxane can add to the bone marrow lowering effects of chemotherapy. This can weaken your immune system, making it easier for you to get sick from being near others who are ill.
• To be certain this medicine is not causing deleterious effects, your blood cells and kidney function will need to be tested often. Do not miss any follow up visits to your doctor for blood or urine tests.
• Since dexrazoxane is given by a healthcare professional as part of your chemotherapy treatment, you are not likely to miss a dose.
• Call your doctor if you miss a chemotherapy appointment.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Speak your doctor at once if you have any of these serious side effects:
· fever, chills, body aches, flu symptoms, sores in your mouth and throat;
· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
· bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.
• Smaller serious side effects may include:
· swelling in your hands or feet;
· hair loss;
· nausea, vomiting, diarrhea, loss of appetite;
· sore throat, trouble swallowing;
· dizziness, weary feeling; or
· pain, swelling, or redness where the medication was injected.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Some cancer medications may be smaller effective if they are used with dexrazoxane. Speak your doctor if your chemotherapy medications include:
· fluorouracil (5-FU, Adrucil);
· cyclophosphamide (Cytoxan, Neosar).
• This list is not complete and another drugs may interact with dexrazoxane. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your doctor or pharmacist can provide more information about dexrazoxane.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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