COLCHICINE AND PROBENECID

(KOL chi seen and pro BEN e sid) Brand:

What is the most significant information I must know about colchicine and probenecid?

• This medicine will not stop a gout onslaught that has already started. Your doctor may prescribe another medications to treat your gout. Hold taking colchicine and probenecid on a regular schedule, even if you take another gout medications.

• You may not announcement the effects of this medication right away. Your gout attacks must occur smaller often as you continue to take colchicine and probenecid. Taking the medication for different months may reason the attacks to stop altogether. It is significant to use the medicine regularly to get the most benefit. Speak your doctor if your symptoms do not improve.

• To be certain this medicine is helping your condition, your doctor will need to check your progress on a regular basis. Your kidney function may also need to be tested. It is significant that you not miss any scheduled visits to your doctor.

• This medicine can reason you to have unusual results with determined medical trials. Speak any doctor who treats you that you are using colchicine and probenecid.

What is colchicine and probenecid?

• Colchicine alters the way your body responds to uric acid crystals. Too many uric acid in the body is what leads to the symptoms of gout (swelling and pain).

• Probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

• The colchicine and probenecid combination is used to prevent gout attacks. This medicine will not cure gout and it will not stop a gout onslaught that has already started.

• Colchicine and probenecid may also be used for purposes another than those listed in this medicine guide.

What must I discuss with my health care provider till taking colchicine and probenecid?

• Till using colchicine and probenecid, speak your doctor if you have:

· heart disease;

· kidney malady or a history of kidney stones;

· liver disease;

· a blood disease;

· stomach problems such as an ulcer or severe intestinal disorder;

· if you drink big amounts of alcohol; or

· if you are receiving a cancer treatment, including chemotherapy or radiation.

• If you have any of these conditions, you may not be able to use colchicine and probenecid, or you may need a dosage adjustment or particular trials during treatment.

• Colchicine and probenecid may be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether this medicine passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• This medicine can reason you to have unusual results with determined medical trials. Speak any doctor who treats you that you are using colchicine and probenecid.

• Older adults may be more sensitive to the side effects of this medication.

How must I take colchicine and probenecid?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor.

• Your doctor may occasionally change your doze to create certain you get the excellent results from this medication.

• You may take this medication with food or milk if it upsets your stomach. You may also use an antacid.

• Drink different full glasses of water each day to prevent kidney stones. Follow your doctor's instructions about the type and amount of liquids you must drink every day.

• Store colchicine and probenecid at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at the following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include blood in your urine, urinating smaller than normal, heartburn, severe diarrhea, nausea, vomiting, fever, severe muscle weakness, mood changes, trouble breathing, seizure (convulsions).

What must I avoid while taking colchicine and probenecid?

• Avoid drinking alcohol, which can raise uric acid levels in your blood and may also magnify your risk of stomach problems caused by colchicine and probenecid.

What are the possible side effects of colchicine and probenecid?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using colchicine and probenecid and call your doctor at once if you have any of these serious side effects:

· painful urination, severe pain in your lower back or side;

· light bruising or bleeding, unusual weakness; or

· severe diarrhea, nausea, vomiting, or stomach pain.

• Continue using colchicine and probenecid and conversation with your doctor if you have any of these smaller serious side effects:

· mild nausea, vomiting, stomach pain, loss of appetite;

· headache;

· dizziness;

· hair loss; or

· warmth or tingly feeling.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect colchicine and probenecid?

• Till taking colchicine and probenecid, speak your doctor if you are using any of the next drugs:

· amphotericin B (Fungizone);

· azathioprine (Imuran);

· cyclophosphamide (Cytoxan);

· flucytosine (Ancobon);

· ganciclovir (Cytovene);

· heparin;

· indomethacin (Indocin);

· interferon (Intron A, Roferon-A);

· ketoprofen (Orudis);

· mercaptopurine (Purinethol);

· methotrexate (Rheumatrex);

· nitrofurantoin (Macrodantin, Macrobid);

· phenylbutazone (Butazolidin);

· plicamycin (Mithracin);

· zidovudine (Retrovir);

· salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Pepto-Bismol, Salflex, Tricosal, and others;

· medicines to treat tuberculosis or viral infections; or

· medication to treat overactive thyroid.

• If you are using any of these drugs, you may not be able to use colchicine and probenecid, or you may need dosage adjustments or particular trials during treatment.

• There may be another drugs not listed that can affect colchicine and probenecid. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist has more information about colchicine and probenecid written for health professionals that you may read.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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