(kloe FAR a been) Brand: Clolar
• Clofarabine can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
• Clofarabine can harm your liver or kidneys. Call your doctor if you have lower back pain, few or no urinating, or blood in your urine.
• Clofarabine is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.
• Clofarabine is used to treat acute lymphoblastic leukemia (a type of blood cancer) in children and young adults up to 21 years old.
• Clofarabine is generally given after another cancer medicines have been tried without successful treatment.
• Clofarabine may also be used for purposes not listed in this medicine guide.
• To create certain clofarabine is safety for you, speak your doctor if you have:
· liver malady; or
· kidney disease.
• FDA pregnancy category D. Do not use clofarabine if you are pregnant. It could harm the unborn child.
• Use birth control to prevent pregnancy while you are receiving clofarabine, whether you are a man or a woman. Clofarabine use by either parent may reason birth defects.
• It is not known whether clofarabine passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are receiving clofarabine.
• Clofarabine is injected into a vein through an IV. A healthcare provider will give you this injection.
• Clofarabine is generally given daily for 5 days in a row during one or more treatment cycles. Your doctor will determine how much treatment cycles you will receive and how often.
• You may receive another medications to help prevent determined side effects of clofarabine.
• Clofarabine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your kidney or liver function may also need to be tested. Your cancer treatments may be delayed based on the results of these tests.
• Call your doctor for instructions if you miss an appointment for your clofarabine injection.
• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.
• This medication can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a doze, avoid allowing your body fluids to come into contact with your hands or another surfaces. Patients and caregivers must wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands till and after removing gloves. Wash soiled clothing and linens apart from another laundry.
• Body fluids must not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have:
· a light-headed feeling, like you might pass out;
· runny or stuffy nose, cough, rapid heart course, trouble breathing, swelling and pain in any part of your body;
· lower back pain, blood in your urine, few or no urinating;
· numbness or tingly feeling near your mouth;
· muscle weakness, tightness, or contraction, overactive reflexes;
· pain, redness, numbness, and peeling skin on your hands or feet;
· quick or slow heart course, weak pulse, feeling short of breath, confusion, fainting;
· numbness or redness on the palms of your hands or the soles of your feet;
· bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
· jaundice (yellowing of the skin or eyes); or
· signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, light bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, mouth sores, unusual weakness.
• General side effects may include:
· nausea, vomiting, diarrhea;
· headache, feeling weary or anxious;
· mild itching or skin rash; or
· warmth, redness, or tingly feeling under your skin.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• Speak your doctor about all another medications you use, especially blood pressure medications.
• Clofarabine can harm your liver or kidneys. This effect is heighten when you also use another medicines deleterious to the liver or kidneys. During your 5-day treatment with clofarabine, you may need to avoid using determined medications. Much another drugs (including some over-the-counter medicines) can be deleterious to the liver or kidneys, such as:
· methotrexate;
· an antibiotic, antifungal medication, antiviral medication, sulfa drug, or tuberculosis medicine;
· birth control pills or hormone replacement therapy;
· heart or blood pressure medication;
· cholesterol-lowering medications--Crestor, Lipitor, Pravachol, Simcor, Vytorin, Zocor, and others;
· gout or arthritis medications (including gold injections);
· HIV/AIDS medications;
· medicines to treat a bowel disorder;
· medicine to prevent organ transplant rejection;
· medicines to treat mental illness;
· another cancer medications;
· pain or arthritis medicines--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;
· seizure medication--carbamazepine, phenytoin, and others; or
· steroids (prednisone and others).
• This list is not complete. Another drugs may interact with clofarabine, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.
• Your doctor or pharmacist can provide more information about clofarabine.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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