RHO (D) IMMUNE GLOBULIN

(ROE D im MYOON GLOB yoo lin) Brand: HyperRHO S/D Full Doze, HyperRHO S/D Mini Doze, MicRhoGAM, MicRhoGAM Ultra-Filtered Plus, RhoGAM, RhoGAM Ultra-Filtered Plus, Rhophylac, WinRho SDF

What is the most significant information I must know about RHo (D) immune globulin?

• You must not receive this medicine if you have ever had an allergic reaction to an immune globulin or if you have immune globulin A (IgA) deficiency with antibody to IgA. You must not receive RHo (D) immune globulin if you have hemolytic anemia (a lack of red blood cells).

• Till you receive this medicine, speak your doctor if you have heart malady or a history of coronary artery malady, tall triglycerides, a bleeding mess, or immune globulin A (IgA) deficiency.

If you are an Rh-negative woman and you become pregnant, you should speak your doctor if you have ever been exposed to Rh-positive blood in your lifetime. This includes exposure from a mismatched blood transfusion, or exposure during your first pregnancy. Your history of exposure and treatment will be extremely significant to every and each one of your pregnancies.

• Call your doctor at once if you have a serious side effect such as fever, chills, shaking, back pain, dark colored urine, rapid breathing, feeling short of breath, urinating smaller than normal, swelling, rapid weight gain, pale skin, light bruising or bleeding, rapid heart course, trouble concentrating, feeling light-headed.

• Do not receive a "live" vaccine for at least 3 months after treatment with RHo (D) immune globulin. The vaccine may not work as well during this time, and may not fully protect you from malady. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

What is RHo (D) immune globulin?

• RHo (D) immune globulin is a sterilized solution made from human blood. Rh is a stuff that most people have in their blood (Rh positive) but some people do not (Rh negative). A face who is Rh negative can be exposed to Rh positive blood through a mismatched blood transfusion or during pregnancy when the child has the opposite blood type. When this exposure happens, the Rh negative blood will respond by making antibodies that will try to destroy the Rh positive blood cells. This can reason medical problems such as anemia (loss of red blood cells), kidney failure, or shock.

• RHo (D) immune globulin is used to prevent an immune response to Rh positive blood in people with an Rh negative blood type. RHo (D) immune globulin may also be used in the treatment of immune thrombocytopenic purpura (ITP).

• RHo (D) immune globulin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till I receive RHo (D) immune globulin?

• You must not receive this medicine if you have ever had an allergic reaction to an immune globulin or if you have immune globulin A (IgA) deficiency with antibody to IgA. You must not receive RHo (D) immune globulin if you have hemolytic anemia (a lack of red blood cells).

• To create certain you can safely receive RHo (D) immune globulin, speak your doctor if you have any of these another conditions:

· heart malady or a history of coronary artery malady (hardened arteries);

· tall triglycerides (a type of thick in the blood);

· a bleeding mess (such as hemophilia); or

· immune globulin A (IgA) deficiency.

• RHo (D) immune globulin is used during and after pregnancy. This medicine is not known to be deleterious to a child during pregnancy or while breast-feeding.

• If you are receiving this medicine to treat a mismatched blood transfusion, speak your doctor if you are pregnant or if you ever plan to become pregnant.

• RHo (D) immune globulin is made from human plasma (part of the blood) which may contain viruses and another infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a little possibility it could transmit malady. Conversation with your doctor about the risks and benefits of using this medication.

If you are an Rh-negative woman and you become pregnant, you should speak your doctor if you have ever been exposed to Rh-positive blood in your lifetime. This includes exposure from a mismatched blood transfusion, or exposure during your first pregnancy. Your history of exposure and treatment will be extremely significant to every and each one of your pregnancies.

How is RHo (D) immune globulin given?

• RHo (D) immune globulin is injected into a muscle or a vein. You will receive this injection in a clinic or hospital setting.

• Your breathing, blood pressure, oxygen levels, and another vital signs will be watched closely for at least 8 hours after you receive immune globulin. Your urine will also need to be tested each 2 to 4 hours.

• For treatment during pregnancy, this medicine is generally given at regular intervals during the recent half of the pregnancy, and again after the child is born.

• For treatment of a mismatched blood transfusion, the medicine is given when symptoms of an immune response appear (when the body starts making Rh antibodies).

• To be certain this medication is helping your condition, your blood will need to be tested often. Your liver and kidney function may also need to be tested. Visit your doctor regularly.

• This medicine can reason false results with determined lab trials for glucose (sugar) in the blood. Speak any doctor who treats you that you are using RHo (D) immune globulin.

What happens if I miss a dose?

• Call your doctor for instructions if you miss an appointment for your RHo (D) immune globulin injection.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while receiving RHo (D) immune globulin?

• Do not receive a "live" vaccine for at least 3 months after treatment with RHo (D) immune globulin. The vaccine may not work as well during this time, and may not fully protect you from malady. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

What are the possible side effects of RHo (D) immune globulin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: rash or hives; feeling light-headed, chest tightness, difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· fever, chills, shaking, back pain, dark colored urine;

· rapid breathing, feeling short of breath.

· urinating smaller than normal or not at all, swelling, rapid weight gain; or

· pale skin, light bruising or bleeding, rapid heart course, trouble concentrating, feeling light-headed.

• Smaller serious side effects may include:

· joint or muscle pain;

· headache, dizziness;

· feeling weak or tired;

· mild itching or skin rash;

· nausea, diarrhea, vomiting, stomach pain; or

· pain or tenderness where the medication was injected.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect RHo (D) immune globulin?

• There may be another drugs that can interact with RHo (D) immune globulin. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about RHo (D) immune globulin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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