Rh (D) immune globulin (WinRhoSD); Immune Globulin; Inj: 600, 1500, 5000 IU;
Immune thrombocytopenic purpura: 250 IU/kg (50 mcg/kg)
IV over o 3-5 min.
Monitor platelet count, red blood cell count,
hemoglobin, and reticulocytes. 250 IU equals 50 mcg. Only use for Rho(D) antigen-positive patients.
Monitor for
hemolysis. A
hemoglobin drop of more than 2 gm/dL occurs in 5-10% of patients with
ITP. If
hemoglobin <10 gm/dL, give 50% dose to
minimize risk of increasing severity of
anemia. Do not use if
baseline hemoglobin is less than 8 gm/dL.