PROPYLTHIOURACIL

(PRO pil THYE oh URE a sil) Brand:

What is the most significant information I must know about propylthiouracil?

• Do not use propylthiouracil if you are pregnant. It could harm the unborn baby.

• Propylthiouracil can pass into breast milk and may harm a nursing child. Do not use propylthiouracil while you are breast-feeding a baby.

• Propylthiouracil can lower blood cells that help your body fight infections. This can create it easier for you to bleed from an injury or get sick from being near others who are ill. Contact your doctor at once if you develop signs of infection.

• Propylthiouracil may reason severe liver symptoms. Call your doctor at once if you have any of these liver symptoms: low fever, itching, nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What is propylthiouracil?

• Propylthiouracil prevents the thyroid gland from producing too many thyroid hormone.

• Propylthiouracil is used to treat hyperthyroidism (overactive thyroid) or Graves' disease.

• Propylthiouracil may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking propylthiouracil?

• You must not use this medicine if you are allergic to propylthiouracil, or if you are breast-feeding a baby.

• If you have any of these another conditions, you may need a doze adjustment or particular tests:

· liver problems; or

· a blood disorder.

• FDA pregnancy category D. Do not use propylthiouracil if you are pregnant. It could harm the unborn child. Use effective birth control, and speak your doctor if you become pregnant during treatment.

• Propylthiouracil can pass into breast milk and may harm a nursing child. Do not use propylthiouracil while you are breast-feeding a baby.

How must I take propylthiouracil?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Take this medication with a full glass of water.

• Propylthiouracil can be taken with or without food.

• Use propylthiouracil regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Propylthiouracil can lower blood cells that help your body fight infections. This can create it easier for you to bleed from an injury or get sick from being near others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

• Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, light bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include nausea, vomiting, stomach pain, headache, joint pain, fever, sore throat, itching, rash, swelling, loss of appetite, numbness or tingling, and feeling restless or drowsy.

What must I avoid while taking propylthiouracil?

• Avoid being around people who are sick or have infections. Speak your doctor at once if you develop signs of infection.

What are the possible side effects of propylthiouracil?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Stop taking propylthiouracil and call your doctor at once if you have a serious side effect such as:

· fever, sore throat, headache, body aches, flu symptoms;

· pale skin, light bruising or bleeding (nosebleeds, bleeding gums), unusual weakness;

· dry cough, trouble breathing; or

· severe blistering, peeling, and red skin rash.

• Propylthiouracil may also reason severe liver symptoms. Call your doctor at once if you have any of these liver symptoms:

· low fever, itching;

· nausea, stomach pain, loss of appetite;

· dark urine, clay-colored stools; or

· jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· upset stomach, vomiting;

· dizziness, spinning sensation;

· mild skin rash or itching;

· mild joint or muscle pain;

· decreased sense of taste; or

· hair loss.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect propylthiouracil?

• Speak your doctor about all another medications you use, especially:

· digoxin (Lanoxin, digitalis);

· theophylline (Elixophyllin, Theo-24, Uniphyl);

· a blood thinner such as warfarin (Coumadin); or

· a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

• This list is not complete and another drugs may interact with propylthiouracil. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about propylthiouracil.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.