PREPARE: Direct: Give undiluted or diluted (preferred) with sterile water, D5W, NS, or other compatible IV solutions.
ADMINISTER: Direct: Give slowly. Do not exceed rate of 50 mg/min.
INCOMPATIBILITIES Solution/additive: Atropine, butorphanol, chlorpheniramine, chlorpromazine, cimetidine, codeine, dimenhydrinate, diphenhydramine, droperidol, ephedrine, fentanyl, glycopyrrolate, hydrocortisone, hydroxyzine, inulin, levorphanol, meperidine, methadone, midazolam, morphine, nalbuphine, norepinephrine, tetracyclines, penicillin G, pentazocine, perphenazine, phenytoin, promazine, prochlorperazine, promethazine, ranitidine, sodium bicarbonate, streptomycin, succinylcholine, triflupromazine, vancomycin. Y-site: Amphotericin B cholesteryl, fenoldopam, TPN.
- Take extreme care to avoid extravasation. Necrosis may result because parenteral solution is highly alkaline.
- Do not use cloudy or precipitated solution.