DROPERIDOL (droe-per'i-dole) Inapsine Classifications: butyrophenone; antiemetic; anxiolytic; Therapeutic: antiemetic; antianxiety Prototype: Haloperidol Pregnancy Category: C |
2.5 mg/mL injection
Butyrophenone derivative structurally and pharmacologically related to haloperidol. Antagonizes emetic effects of morphine-like analgesics and other drugs that act on chemoreceptor trigger zone.
Sedative property reduces anxiety and motor activity without necessarily inducing sleep; patient remains responsive. Has antiemetic properties, and potentiates other CNS depressants.
To produce tranquilizing effect and to reduce nausea and vomiting during surgical and diagnostic procedures. Also for premedication, during induction, and as adjunct in maintenance of general or regional anesthesia. Principally used in fixed combination with the potent narcotic analgesic fentanyl (Innovar) to produce neuroleptanalgesia (quiescence, reduced motor activity, and indifference to pain and environmental stimuli) to permit carrying out a variety of diagnostic and minor surgical procedures.
IV antiemetic in cancer chemotherapy.
Known or suspected QT elongation; history of torsades de pointes; known intolerance to droperidol; hypokalemia, hypomagnesia, pregnancy (category C), lactation. Safe use in children <2 y is not established.
Older adult, debilitated, alcoholism, and other poor-risk patients; MAOI therapy; Parkinson's disease; cardiac disease; cardiac bradyarrhythmias, cardiac arrhythmias, CHF, hypotension; liver and kidney impairment or disease.
Postoperative Nausea and Vomiting Prevention Using Continual ECG Monitoring Adult: IV/IM 2.5 mg; additional doses of 1.25 mg may be given Child: IV/IM 0.1 mg/kg (max: 2.5 mg) Renal Impairment Due to increased risk of QT prolongation and torsades de points continuous monitoring is required. |
Intravenous
PREPARE: Direct: Give undiluted. ADMINISTER: Direct: Give at a rate of 10 mg or fraction thereof over 3060 sec. INCOMPATIBILITIES Solution/additive: barbiturates. Y-site: Allopurinol, amphotericin B cholesteryl complex, cefepime, cefotetan, fluorouracil, foscarnet, furosemide, heparin, leucovorin, methotrexate, nafcillin, piperacillin/tazobactam. |
Assessment & Drug Effects