METFORMIN AND SAXAGLIPTIN

(met FOR min and SAX a GLIP tin) Brand: Kombiglyze XR

What is the most significant information I must know about metformin and saxagliptin?

• You must not use this medicine if you have kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• If you need to have surgery or any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking this medication.

• This medication may reason a serious condition called lactic acidosis. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or weary.

What is metformin and saxagliptin?

• Metformin and saxagliptin are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) manufacture in the liver and decreasing absorption of glucose by the intestines. Saxagliptin works by regulating the levels of insulin your body produces after eating.

• The combination of metformin and saxagliptin is used to treat type 2 diabetes. This medicine is not for treating type 1 diabetes.

• Metformin and saxagliptin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking metformin and saxagliptin?

• You must not use this medicine if you are allergic to metformin (Actoplus Met, Avandamet, Fortamet, Glucophage, Riomet) or saxagliptin (Onglyza), if you have kidney malady, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• If you need to have surgery or any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking metformin and saxagliptin. Be certain your caregivers know onward of time that you are using this medication.

• Some people taking this medication develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney malady, congestive heart failure, a severe infection, if you are dehydrated, or if you drink big amounts of alcohol. Conversation with your doctor about your risk.

• To create certain metformin and saxagliptin is safety for you, speak your doctor if you have:

· liver disease;

· heart malady;

· pancreatitis;

· tall triglycerides (a type of thick in the blood);

· gallstones;

· a history of alcoholism; or

· if you are over 80 years old.

• Determined oral diabetes medications may magnify your risk of serious heart problems. However, not treating your diabetes can hurt your heart and another organs. Conversation to your doctor about the risks and benefits of taking metformin and saxagliptin.

• FDA pregnancy category B. This medicine is not expected to be deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether this medication passes into breast milk or if it could harm a nursing child. Speak your doctor if you are breast-feeding a baby.

How must I take metformin and saxagliptin?

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Take metformin and saxagliptin with a meal.

• Do not crush, chew, or interrupt an extended-release tablet. Swallow it intact.

• Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, famine, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always hold a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, heavy candy, crackers, raisins, and non-diet soda. Be certain your family and close friends know how to help you in an emergency.

• If you have severe hypoglycemia and can't ate or drink, use a glucagon injection. Your doctor can prescribe a glucagon abnormal injection kit and speak you how to use it.

• Check your blood sugar carefully during times of stress, travel, diseases, surgery or medical abnormal, vigorous exercice, or if you drink alcohol or skip meals. These things can affect your glucose levels and your doze needs may also change. Do not change your medicine doze or schedule without your doctor's advice.

• Your doctor may want you to stop taking this medication for a short time if you become ill, have a fever or infection, or if you have surgery or a medical abnormal.

• This medication is only part of a complete program of treatment that may also include diet, exercice, weight control, foot care, and eye care. Follow your diet, medicine, and exercice routines very closely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember (be certain to take the medication with food). Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What must I avoid while taking metformin and saxagliptin?

• Avoid drinking alcohol. It lowers blood sugar and may magnify your risk of lactic acidosis.

What are the possible side effects of metformin and saxagliptin?

• Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or weary.

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using this medication and call your doctor at once if you have:

· severe pain in your upper stomach spreading to your back, nausea and vomiting, quick heart rate;

· pain or burning when you urinate; or

· swelling or rapid weight gain.

• General side effects may include:

· diarrhea, mild nausea;

· headache; or

· cool symptoms such as runny or stuffy nose, sneezing, sore throat.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect metformin and saxagliptin?

• Other drugs may magnify or decrease the effects of metformin and saxagliptin on lowering your blood sugar. Speak your doctor about all medications you use. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about metformin and saxagliptin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.