METFORMIN AND ROSIGLITAZONE
(met FOR min and ROE zi GLI ta zone) Brand: Avandamet
What is the most significant information I must know about metformin and rosiglitazone?
• Taking this medication may magnify your risk of serious heart problems. Therefore, metformin and rosiglitazone is accessible only to determined people with type 2 diabetes that can't be controlled with another diabetes medications.
• You must not use this medication if you have severe or uncontrolled heart failure, or severe kidney problems. Do not use this medication if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Metformin and rosiglitazone is not recommended for use with insulin, and is not for treating type 1 diabetes.
• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking metformin and rosiglitazone.
• Metformin and rosiglitazone can reason or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.
• This medication may reason a serious condition called lactic acidosis. Get abnormal medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, quick or uneven heart course, dizziness, or feeling very weak or weary.
What is metformin and rosiglitazone?
• Metformin and rosiglitazone is a combination of two oral diabetes medicines that help control blood sugar levels. This medication is for people with type 2 diabetes, and is not for treating type 1 diabetes.
• Taking metformin and rosiglitazone may magnify your risk of serious heart problems, such as heart onslaught or stroke. Therefore, metformin and rosiglitazone is accessible only to determined people with type 2 diabetes that can't be controlled with another diabetes medications.
• Metformin and rosiglitazone is accessible only under a particular program called Avandia-Rosiglitazone Medicines Access Program. You should be registered in the program and sign documents stating that you understand the risks and benefits of taking this medication.
• Metformin and rosiglitazone may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking metformin and rosiglitazone?
• You must not use metformin and rosiglitazone if you are allergic to it, or if you have:
· severe or uncontrolled heart failure;
· severe kidney problems;
· metabolic acidosis; or
· if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
• If you need to have any type of x-ray or CT scan using a paint that is injected into your veins, you will need to temporarily stop taking metformin and rosiglitazone.
• Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney malady, congestive heart failure, a severe infection, if you are dehydrated, or if you drink big amounts of alcohol. Conversation with your doctor about your individual risk.
• To create certain this medicine is safety for you, speak your doctor if you have:
· heart malady, or a history of heart onslaught or stroke;
· liver malady; or
· eye problems caused by diabetes.
• Taking this medication may magnify your risk of serious heart problems. However, not treating your diabetes can hurt your heart and another organs. Conversation to your doctor about the risks and benefits of treating your diabetes with metformin and rosiglitazone.
• Women may be more likely than men to have bone fractures in the upper hand, arm, or foot while taking medication that contains rosiglitazone. Conversation with your doctor if you are concerned about this possibility.
• FDA pregnancy category C. It is not known whether this medication will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant.
• Some women using metformin and rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Conversation with your doctor about the need for birth control.
• It is not known whether metformin and rosiglitazone passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.
How must I take metformin and rosiglitazone?
• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.
• Take this medication with food if it upsets your stomach.
• Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office.
• Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, famine, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always hold a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, heavy candy, crackers, raisins, and non-diet soda. Be certain your family and close friends know how to help you in an emergency.
• If you have severe hypoglycemia and can't ate or drink, use a glucagon injection. Your doctor can prescribe a glucagon abnormal injection kit and speak you how to use it.
• Check your blood sugar carefully during times of stress, travel, diseases, surgery or medical abnormal, vigorous exercice, or if you drink alcohol or skip meals. These things can affect your glucose levels and your doze needs may also change. Do not change your medicine doze or schedule without your doctor's advice.
• If you take extra vitamin B12 while you are taking metformin and rosiglitazone, take only the amount of vitamin B12 that your doctor has prescribed.
• Metformin and rosiglitazone is only part of a treatment program that may also include diet, exercice, weight control, blood sugar testing, and particular medical care. Follow your doctor's instructions very closely.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
What must I avoid while taking metformin and rosiglitazone?
• Avoid drinking alcohol while taking metformin and rosiglitazone.
What are the possible side effects of metformin and rosiglitazone?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.
• Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, quick or uneven heart course, dizziness, or feeling very weak or weary.
• Call your doctor at once if you have:
· chest pain or hard feeling, pain spreading to the jaw or shoulder, nausea, sweating, common ill feeling;
· sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
· shortness of breath (even with mild exertion), swelling, rapid weight gain;
· pale skin, light bruising or bleeding, weakness;
· nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
· changes in your vision.
• General side effects may include:
· cool symptoms such as stuffy nose, sneezing, sore throat;
· headache; or
· upset stomach, diarrhea.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect metformin and rosiglitazone?
• Speak your doctor if you use insulin. Taking metformin and rosiglitazone while you are using insulin may magnify your risk of serious heart problems.
• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with metformin and rosiglitazone, especially:
· cimetidine;
· gemfibrozil; or
· an antibiotic--rifampin, trimethoprim, vancomycin.
• You may be more likely to have hyperglycemia (high blood sugar) if you also take another drugs that can raise blood sugar, such as:
· isoniazid;
· steroids (prednisone and others);
· niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
· phenothiazines (Compazine and others);
· thyroid medication (Synthroid and others);
· birth control pills and another hormones; and
· diet pills or medicines to treat asthma, colds or allergies.
• These lists are not complete and much another medicines can magnify or decrease the effects of metformin and rosiglitazone on lowering your blood sugar. This includes prescription and over-the-counter medicines, vitamins, and herbal commodity. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
• Your pharmacist can provide more information about metformin and rosiglitazone.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
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