ISONIAZID AND RIFAMPIN

(eye so NYE a zid and RIF am pin) Brand: IsonaRif, Rifamate

What is the most significant information I must know about isoniazid and rifampin?

• You must not use isoniazid and rifampin if you have active liver malady (including hepatitis or cirrhosis), or a history of liver problems caused by taking isoniazid.

• Serious and sometimes fatal liver problems may occur during treatment with isoniazid and rifampin or after you stop taking this medicine, even months after stopping. The risk of liver problems is highest in adults between the ages of 35 and 65. Your liver function may need to be checked each month while you are taking this medicine.

• Call your doctor right away if you have: nausea, upper stomach pain, loss of appetite, and feeling weak or tired.

• Avoid drinking alcohol. It may magnify your risk of liver hurt while you are taking isoniazid and rifampin.

What is isoniazid and rifampin?

• Isoniazid and rifampin are antibiotics that fight bacteria.

• Isoniazid and rifampin is a combination medication used to treat tuberculosis (TB).

• Isoniazid and rifampin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking isoniazid and rifampin?

• You must not use this medication if you are allergic to isoniazid or rifampin, or if you have active liver malady (including hepatitis or cirrhosis), or a history of liver problems caused by taking isoniazid.

• To create certain isoniazid and rifampin is safety for you, speak your doctor if you have:

· liver disease;

· kidney disease;

· diabetes;

· gout;

· seizures; or

· if you drink alcohol each day.

• It is not known whether isoniazid and rifampin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• Isoniazid and rifampin can create birth control pills smaller effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking isoniazid and rifampin.

• Isoniazid and rifampin can pass into breast milk and may harm a nursing child. Speak your doctor if you are breast-feeding a baby.

How must I take isoniazid and rifampin?

• Your doctor will perform blood trials to create certain you do not have conditions that would prevent you from safely using isoniazid and rifampin.

• Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.

• Take isoniazid and rifampin on an empty stomach, at least 1 hour till or 2 hours after a meal.

• Your doctor may have you take extra vitamin B6 while you are taking isoniazid and rifampin. Take only the amount of vitamin B6 that your doctor has prescribed.

• Use this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared. Skipping doses may also magnify your risk of further infection that is resistant to antibiotics. Isoniazid and rifampin will not treat a viral infection such as the general cool or flu.

• Isoniazid and rifampin is generally given before lab trials show that the infection has cleared.

• This medicine can reason unusual results with determined medical trials. Speak any doctor who treats you that you are using isoniazid and rifampin.

• Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking isoniazid and rifampin?

• Do not wear soft contact lenses while taking isoniazid and rifampin. Rifampin may turn your tears a red-orange color. This effect could permanently discolor soft contact lenses.

• Avoid drinking alcohol. It may magnify your risk of liver hurt while you are taking isoniazid and rifampin.

What are the possible side effects of isoniazid and rifampin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· nausea, upper stomach pain, feeling weak or weary, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

· vision changes, confusion, hallucinations, unusual thoughts or behavior;

· fever, unusual weakness, pale skin; or

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

• General side effects may include:

· red-orange coloration of tears, sweat, saliva, urine, or stools;

· numbness, tingling, itching, mild rash;

· drowsiness, dizziness, headache;

· muscle pain or weakness;

· heartburn, gas, diarrhea; or

· mouth pain.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect isoniazid and rifampin?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with isoniazid and rifampin, especially:

· an anticoagulant (warfarin, Coumadin).

• This list is not complete. Another drugs may interact with isoniazid and rifampin, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about isoniazid and rifampin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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