ENTECAVIR

(en TEK a vir) Brand: Baraclude

What is the most significant information I must know about entecavir?

• You must not take this medicine if you are allergic to entecavir, or if you also have HIV (human immunodeficiency virus) that is not being treated.

• Some people have developed a life-threatening condition called lactic acidosis while taking enteavir. Early signs of lactic acidosis usually get worse over time and this condition can be fatal. Get abnormal medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cool feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart course, dizziness, or feeling very weak or tired.

• Entecavir may also reason severe liver symptoms such as nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Call your doctor at once if you have any of these symptoms.

• Some people with hepatitis B develop liver symptoms after they stop taking entecavir, even months after stopping. Your doctor may want to check your liver function on a regular basis for different months after you stop using this medicine. Do not miss any scheduled visits.

What is entecavir?

• Entecavir is an antiviral medicine. Entecavir prevents determined virus cells from multiplying in your body

• Entecavir is used to treat chronic hepatitis B.

• Entecavir may also be used for another purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking entecavir?

• You must not take this medicine if you are allergic to entecavir, or if you also have HIV (human immunodeficiency virus) that is not being treated.

• If you have determined conditions, you may need a doze adjustment or particular trials to safely take this medicine. Till you take entecavir, speak your doctor if you are allergic to any drugs, or if you have:

· HIV or AIDS;

· kidney disease;

· liver malady; or

· if you have had a liver transplant.

• Some people have developed a life-threatening condition called lactic acidosis while taking entecavir. You may be more likely to develop lactic acidosis if you have liver or kidney malady, congestive heart failure, or if you drink big amounts of alcohol. Conversation with your doctor about your individual risk.

• FDA pregnancy category C. It is not known whether entecavir is deleterious to an unborn child. Till you take entecavir, speak your doctor if you are pregnant or plan to become pregnant during treatment.

• Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

• It is not known whether entecavir passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

How must I take entecavir?

• Take this medicine exactly as it was predesigned for you. Do not take the medicine in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

• You may be required to be tested for HIV till you start taking entecavir. Follow your doctor's instructions.

• Take entecavir with a full glass of water.

• Take entecavir on an empty stomach, at least 2 hours till or 2 hours after eating.

• Measure the liquid form (oral solution) of entecavir with the dosing spoon provided with this medicine. Keep the dosing spoon in an upright position and fill it slowly before the liquid reaches the mark of your correct doze. Rinse the dosing spoon with water after every use. If you do not receive a dosing spoon with your medicine, ask your pharmacist for one.

• Store entecavir at room temperature away from moisture and heat.

• Hold the tablets in a tightly-closed container.

• Hold the bottle of oral liquid in its original carton to help protect the medication from easy. Throw away any unused entecavir oral liquid after the expiration date on the label has passed.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, skip the missed doze and take the medication at your following regularly scheduled time. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Symptoms of an entecavir overdose are not known.

What must I avoid while taking entecavir?

• Taking entecavir will not prevent you from passing hepatitis B to another people through unprotected sex or sharing of needles. Conversation with your doctor about safety methods of preventing hepatitis transmission during sex, such as using a condom and spermicide. Sharing drug or medication needles is never safety, even for a healthy person.

What are the possible side effects of entecavir?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• This medicine may reason lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get abnormal medical help if you have even mild symptoms of lactic acidosis, such as:

· muscle pain or weakness;

· numb or cool feeling in your arms and legs;

· trouble breathing;

· feeling dizzy, light-headed, weary, or very weak;

· stomach pain, nausea with vomiting; or

· slow or uneven heart rate.

• Entecavir may also reason severe liver symptoms. Call your doctor at once if you have any of these liver symptoms:

· low fever;

· nausea, stomach pain, loss of appetite;

· dark urine, clay-colored stools; or

· jaundice (yellowing of the skin or eyes).

• Smaller serious side effects may include:

· mild nausea, vomiting, diarrhea, upset stomach;

· temporary hair loss;

· headache;

· skin rash; or

· sleep problems (insomnia).

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect entecavir?

• Till taking entecavir, speak your doctor if you are using any of the next drugs:

· drugs that weaken your immune system (such as cancer medication or steroids);

· amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);

· cyclosporine (Neoral, Sandimmune, Gengraf);

· pentamidine (Nebupent, Pentam);

· sirolimus (Rapamune), tacrolimus (Prograf);

· antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled); or

· any another antiviral medicines.

• This list is not complete and there may be another drugs that can interact with entecavir. Speak your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start using a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about entecavir.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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