Gait disturbances (attributed to benzodiazepine
toxicity) occurred in 2 patients given
triazolam, and
lorazepam or flurazepam, with
omeprazole. Another patient taking
diazepam and
omeprazole became wobbly and sedated. Lansoprazole, pantoprazole, or rabeprazole appear not to interact with
diazepam to a clinically relevant extent. Diazepam
serum levels are increased by esomeprazole but the
clinical relevance of this is unknown.
Information is sparse. Bear this interaction in mind if excessive benzodiazepine effects occur.