Losec , Prilosec, Prilosec OTC, Zegerid
Classifications: proton pump inhibitor; Therapeutic: antiulcer; proton pump inhibitor
Pregnancy Category: C
10 mg, 20 mg, 40 mg capsules; 20 mg powder for oral suspension
An antisecretory compound that is a gastric acid pump inhibitor. Suppresses gastric acid secretion by inhibiting the H+, K+-ATPase enzyme system [the acid (proton H+) pump] in the parietal cells.
Suppresses gastric acid secretion relieving gastrointestinal distress and promoting ulcer healing.
Duodenal and gastric ulcer. Gastroesophageal reflux disease including severe erosive esophagitis (4 to 8 wk treatment). Long-term
treatment of pathologic hypersecretory conditions such as Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic
mastocytosis. In combination with clarithromycin to treat duodenal ulcers associated with Helicobacter pylori.
Healing or prevention of NSAID-related ulcers.
Long-term use for gastroesophageal reflux disease (GERD), duodenal ulcers; proton pump inhibitors (PPIs), hypersensitivity;
children <2 y; use of OTC formulation in children <18 y or GI bleeding; use of Zegerid in metabolic alkalosis, hypocalcemia,
vomiting, GI bleeding; pregnancy (category C); lactation.
Dysphagia; metabolic or respiratory alkalosis; hepatic disease.
Route & Dosage
|Gastroesophageal Reflux, Erosive Esophagitis, Duodenal Ulcer
Adult: PO 20 mg once/d for 48 wk
Adult: PO 20 mg b.i.d. for 48 wk
Adult: PO 60 mg once/d up to 120 mg t.i.d.
Duodenal Ulcer Associated with H. pylori
Adult: PO 40 mg once/d for 14 d, then 20 mg/d for 14 d, in combination with clarithromycin 500 mg t.i.d. for 14 d
- Give before food, preferably breakfast; capsules must be swallowed whole (do not open, chew, or crush).
- Note: Antacids may be administered with omeprazole.
Adverse Effects (≥1%)CNS:
Headache, dizziness, fatigue
Diarrhea, abdominal pain, nausea, mild transient increases in liver function tests. Urogenital:
Hematuria, proteinuria. Skin:
Diagnostic Test Interference
Omeprazole has been reported to significantly impair peak cortisol response to exogenous ACTH. This finding is undergoing further investigation.
Concomitant administration of diazepam
and omeprazole may increase diazepam
concentrations. Concomitant administration of phenytoin
and omeprazole may increase phenytoin
level. Concomitant administration of warfarin
and omeprazole may increase warfarin
levels. Herbal: Ginkgo, St. John's wort
may decrease plasma concentrations.
Poorly from GI tract; 3040% reaches systemic circulation. Onset:
0.53.5 h. Peak:
Peak inhibition of gastric acid secretion: 5 d. Metabolism:
In liver. Elimination:
80% in urine, 20% in feces. Half-Life:
Assessment & Drug Effects
- Lab tests: Monitor urinalysis for hematuria and proteinuria. Periodic liver function tests with prolonged use.
Patient & Family Education
- Report any changes in urinary elimination such as pain or discomfort associated with urination, or blood in urine.
- Report severe diarrhea; drug may need to be discontinued.