ATROPINE AND PRALIDOXIME

(AT roe peen and PRAL i DOX eem) Brand: DuoDote

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What is the most significant information I must know about atropine and pralidoxime?

• If possible, till you receive atropine and pralidoxime, speak your doctor if you have heart malady, coronary artery malady, a heart rhythm mess, tall blood pressure, narrow-angle glaucoma, kidney malady, enlarged prostate, urination problems, a breathing mess such as asthma or COPD, if you are allergic to any medicine, or if you have recently had a heart attack.

• Also speak your doctor if you are pregnant or breast-feeding.

• In an abnormal situation it may not be possible till you are treated to speak your caregivers about your health conditions or if you are pregnant or breast-feeding. Create certain any doctor caring for you afterward knows that you have received this medication.

What is atropine and pralidoxime?

Atropine blocks the action of chemical called acetylcholine (ah see til KO leen), which may exist in tall levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

• The combination of atropine and pralidoxime is used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

• This medicine is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

Atropine and pralidoxime may also be used for purposes not listed in this medicine guide.

What must I discuss with my health care provider till receiving atropine and pralidoxime?

• If possible, till you receive atropine and pralidoxime, speak your doctor if you have:

· an allergy to any medication;

· heart malady, coronary artery disease;

· tall blood pressure;

· kidney disease;

· asthma, COPD (chronic obstructive pulmonary disorder), bronchitis, emphysema, or another breathing problem;

· a heart rhythm disorder;

· narrow-angle glaucoma;

· an enlarged prostate or urination problems; or

· if you have recently had a heart attack.

• FDA pregnancy category C. It is not known whether atropine and pralidoxime will harm an unborn child. Speak your doctor if you are pregnant.

Atropine and pralidoxime can pass into breast milk and may harm a nursing child. Speak your doctor if you are breast-feeding a baby.

• In an abnormal situation, it may not be possible till you are treated with atropine and pralidoxime to speak your caregivers if you are pregnant or breast-feeding. Create certain any doctor caring for your pregnancy or your child knows you have received this medication.

How is atropine and pralidoxime given?

Atropine and pralidoxime is injected into a muscle in your upper thigh. A healthcare provider will give you this injection.

Atropine and pralidoxime is generally given as soon as possible after the onset of poisoning symptoms. If you still have symptoms after 10 to 15 minutes, you will receive 2 more injections.

• Your breathing, blood pressure, oxygen levels, kidney function, and another vital signs will be watched closely while you are receiving this medication.

• After treatment with atropine and pralidoxime, you may be watched for up to 72 hours to create certain the medication has been effective and you no longer have any effects of the poison.

What happens if I miss a dose?

• Since atropine and pralidoxime is given by a healthcare professional in an abnormal setting, you are not likely to miss a dose.

What happens if I overdose?

• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

• Overdose may occur if you receive atropine and pralidoxime but you have not actually been exposed to the specific poisons this medicine is designed to treat. Symptoms may include vision problems, feeling unsteady, loss of balance or coordination, trouble concentrating, quick heart course, confusion, hallucinations (seeing or hearing things), decreased sweating, hot and dry skin, fainting, weak or shallow breathing, or breathing that stops.

What must I avoid after receiving atropine and pralidoxime?

• Avoid becoming overheated or dehydrated during exercice and in hot weather. Atropine can decrease sweating and you may be more prone to heat stroke for a short time after receiving this medication.

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of atropine and pralidoxime?

• Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medicine, or if you are having any serious side effects.

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Speak your caregivers at once if you have a serious side effect such as:

· pounding heartbeats or fluttering in your chest;

· painful or difficult urination;

· trouble swallowing;

· feeling like you might pass out;

· confusion;

· loss of movement in any part of your body;

· slow heart course, weak pulse, fainting, slow breathing (breathing may stop); or

· chest pain or hard feeling, pain spreading to the hand or shoulder, nausea, sweating, common ill feeling.

• Smaller serious side effects may include:

· dry mouth, dry nose, dry skin;

· dry eyes, blurred vision;

· heighten sensitivity of your eyes to light;

· headache;

· dizziness, drowsiness;

· muscle weakness;

· constipation, stomach pain, bloating, nausea, vomiting;

· loss of interest in sex, impotence; or

· mild skin rash.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect atropine and pralidoxime?

• If possible, till you receive this medicine, speak your doctor about all another medicines you use, especially:

· aminophylline (Phyllocontin, Truphylline);

· morphine (Avinza, Kadian, MS Contin, Oramorph);

· reserpine;

· theophylline (Elixophyllin, Theo-24, Uniphyl);

· a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or

· a tranquilizer such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

• This list is not complete and another drugs may interact with atropine and pralidoxime. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about atropine and pralidoxime.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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