Fluconazole reduces the conversion of losartan to its active metabolite
and decreases the metabolism
, but does not appear to influence the pharmacokinetics
of eprosartan. Candesartan and valsartan
also seem unlikely to interact with fluconazole
. Itraconazole does not significantly affect the pharmacokinetics
or antihypertensive effects of losartan. Ketoconazole does not affect the pharmacoki- netics of eprosartan or losartan.
Where an interaction was noted, the effects were modest, and no clinically significant effect is expected.