ANGIOTENSIN II RECEPTOR ANTAGONISTS AND AZOLES

Fluconazole reduces the conversion of losartan to its active metabolite and decreases the metabolism of irbesartan, but does not appear to influence the pharmacokinetics of eprosartan. Candesartan and valsartan also seem unlikely to interact with fluconazole. Itraconazole does not significantly affect the pharmacokinetics or antihypertensive effects of losartan. Ketoconazole does not affect the pharmacoki- netics of eprosartan or losartan.
Where an interaction was noted, the effects were modest, and no clinically significant effect is expected.
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