Fluconazole reduces the conversion of losartan to its active
metabolite and decreases the
metabolism of
irbesartan, but does not appear to influence the
pharmacokinetics of eprosartan. Candesartan and
valsartan also seem unlikely to interact with
fluconazole. Itraconazole does not significantly affect the
pharmacokinetics or antihypertensive effects of losartan. Ketoconazole does not affect the pharmacoki- netics of eprosartan or losartan.
Where an interaction was noted, the effects were modest, and no clinically significant effect is expected.