FLUCONAZOLE ![]() (flu-con'a-zole) ![]() Diflucan Classifications: antibiotic; azole antifungal; Therapeutic: azole antifungal antibiotic Pregnancy Category: C |
50 mg, 100 mg, 150 mg, 200 mg tablets; 10 mg/mL, 40 mg/mL suspension; 2 mg/mL injection
Fungistatic, but may also be fungicidal depending on concentration. Interferes with formation of ergosterol, the principal sterol in the fungal cell membrane leading to cell death.
Antifungal properties are related to the drug effect on the functioning of fungal cell membrane.
Cryptococcal meningitis and oropharyngeal and systemic candidiasis, both commonly found in AIDS and other immunocompromised patients; vaginal candidiasis.
Hypersensitivity to fluconazole or other azole antifungals; pregnancy (category C).
AIDS or malignancy; hepatic impairment; structural cardiac disease; history of torsades de pointes; renal impairment or failure; lactation.
Oropharyngeal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg/d x 14 d Child: PO/IV 36 mg/kg/d x 14 d Esophageal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg q.d. x 3 wk Child/Infant: PO/IV 36 mg/kg/d x 21 d Systemic Candidemia Adult: PO/IV 400 mg day 1, then 200 mg q.d. x 4 wk Child/Infant/Nenonate (>14 d): PO/IV 6 mg/kg q12h x 28 d Neonate (014 d): IV 6 mg/kg q72h Vaginal Candidiasis Adult: PO 150 mg x 1 dose Cryptococcal Meningitis Adult: PO/IV 400 mg day 1, then 200 mg q.d. x 1012 wk Child/Infant/Neonate (>14 d): PO/IV 12 mg/kg day 1, then 612 mg/kg/d x 1012 wk Neonate (014 d): IV 612 mg/kg day 1, then 612 mg/kg q48h Premature Neonates (014 d): IV 56 mg/kg q72h Renal Impairment Clcr ≤50 mL/min (without concurrent dialysis): give 50% of maintenance dose Dialysis: Administer full dose post-dialysis |
Intravenous PREPARE: Continuous: Packaged ready for use as a 2 mg/mL solution. Remove wrapper just prior to use. ADMINISTER: Continuous: Give at a maximum rate of approximately 200 mg/h. Give after hemodialysis is completed.
INCOMPATIBILITIES Solution/additive: Trimethoprim-sulfamethoxazole. Y-site: Amphotericin B, amphotericin B cholesteryl, ampicillin, calcium gluconate, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, chloramphenicol, clindamycin, diazepam, digoxin, erythromycin, furosemide, haloperidol, hydroxyzine, imipenem-cilastatin, pentamidine, piperacillin, ticarcillin, trimethoprim-sulfamethoxazole. |
Assessment & Drug Effects
Patient & Family Education