Classifications: angiotensin ii receptor antagonist; antihypertensive; Therapeutic: antihypertensive; angiotensin ii receptor antagonist
Pregnancy Category: C first trimester; D second and third trimester
40 mg, 80 mg, 160 mg capsules
An angiotensin II receptor (type AT1) antagonist that blocks the angiotensin converting enzyme (ACE); it inhibits the binding of angiotensin II to the AT1 receptors found in many tissues (e.g., vascular smooth muscle, adrenal glands). Angiotensin II is a potent vasoconstrictor
and primary vasoactive hormone of the reninangiotensinaldosterone system.
Blocking the angiotensin II receptor results in vasodilation and blocking of the aldosterone-secreting effects of angiotensin
II, thus resulting in an antihypertensive effect.
Treatment of hypertension, heart failure.
Hypersensitivity to valsartan or losartan; pregnancy [(category C) first trimester, (category D) second and third trimesters],
lactation; severe heart failure with compromised renal function.
Severe renal or hepatic impairment; renal artery stenosis; hypovolemia; congestive heart failure. Safety and efficacy in
children <18 y are not established.
Route & Dosage
Adult: PO 80 mg q.d. (max: 320 mg q.d.)
Adult: PO Start with 40 mg b.i.d. and titrate up to 160 mg b.i.d.
Hemodialysis: Adjustment not needed
- Give on an empty stomach.
- Correct volume depletion prior to initiation of therapy to prevent hypotension.
- Reduce dosage with severe hepatic or renal impairment.
- Note: Daily dose may be titrated up to 320 mg.
- Store at 15°30° C (59°86° F).
Adverse Effects (≥1%)Body as a Whole:
Headache, dizziness. GI:
Diarrhea, nausea. Respiratory:
Rapidly from GI tract, 25% bioavailability. Onset:
Blood pressure decreased in 2 wk. Peak:
Plasma levels, 24 h; blood pressure effect 4 wk. Distribution:
99% protein bound. Metabolism:
In the liver. Elimination:
Primarily in feces. Half-Life:
Assessment & Drug Effects
- Monitor BP periodically; take trough readings, just prior to the next scheduled dose, when possible.
- Lab tests: Monitor liver function tests, BUN and creatinine, serum potassium, and CBC with differential, periodically.
Patient & Family Education
- Inform physician immediately if you become pregnant.
- Note: Maximum pressure lowering effect is usually evident between 2 and 4 wk after initiation of therapy.
- Notify physician of episodes of dizziness, especially those that occur when making position changes.