TRAMETINIB
(tra ME ti nib) Brand: Mekinist
What is the most significant information I must know about trametinib?
• Follow all directions on your medication label and package. Speak every of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What is trametinib?
• Trametinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
• Trametinib is used to treat a determined type of metastatic melanoma (skin cancer that has spread to another parts of the body).
• Trametinib may also be used for purposes not listed in this medicine guide.
What must I discuss with my healthcare provider till taking trametinib?
• You must not use trametinib if you are allergic to it.
• To create certain trametinib is safety for you, speak your doctor if you have:
· tall blood pressure;
· lung disease;
· liver or kidney malady;
· a history of eye problems (especially a problem with your retina); or
· if you have ever been treated with dabrafenib or vemurafenib to treat your melanoma.
• Using trametinib may magnify your risk of developing another types of skin cancer. Ask your doctor about your specific risk. Speak your doctor if you announcement any new skin symptoms such as redness, sores that will not heal, or a mole that has changed in size or color.
• FDA pregnancy category D. Do not use trametinib if you are pregnant. It could harm the unborn child. Speak your doctor if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 4 months after your treatment ends.
• This medicine may affect fertility (your capacity to have children), whether you are a man or a woman.
• It is not known whether trametinib passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.
How must I take trametinib?
• Your doctor will perform blood trials to create certain you have the correct tumor type to be treated with trametinib.
• Trametinib is generally taken once daily. Follow all directions on your prescription label. Do not take this medication in larger or less amounts or for longer than recommended.
• Take trametinib on an empty stomach, at least 1 hour till or 2 hours after a meal.
• Do not crush, chew, interrupt, or open a trametinib capsule. Swallow it intact.
• Your doctor will need to check your skin on a regular basis while you are using trametinib.
• Your blood pressure will need to be checked often. Your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG) each 2 or 3 months during your treatment. You may also need regular vision examinations while taking trametinib.
• Store at room temperature away from moisture and heat.
What happens if I miss a dose?
• Take the missed doze as soon as you remember. Skip the missed doze if your following doze is smaller than 12 hours away. Do not take extra medication to create up the missed doze.
What happens if I overdose?
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
What must I avoid while taking trametinib?
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What are the possible side effects of trametinib?
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.
• Stop using trametinib and call your doctor at once if you have:
· chest pain, dry cough, wheezing, feeling short of breath;
· severe skin rash or irritation;
· shortness of breath (even with mild exertion), swelling, rapid weight gain;
· few or no urinating;
· vision changes, vision loss, seeing flashes of easy or "floaters" in your vision, seeing halos near lights;
· severe skin rash, skin pain, redness or warmth, redness and peeling skin on your hands or foots;
· swollen glands; or
· dangerously tall blood pressure (severe headache or dizziness, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
• General side effects may include:
· diarrhea;
· common ill feeling; or
· acne, mild skin rash.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
What another drugs will affect trametinib?
• Another drugs may interact with trametinib, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Speak every of your health care providers about all medicines you use now and any medication you start or stop using.
Where can I get more information?
• Your pharmacist can provide more information about trametinib.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.