| TAMSULOSIN HYDROCHLORIDE
Classifications: alpha-adrenergic antagonist; Therapeutic: smooth muscle relaxant of bladder outlet & prostate gland
Prototype: Prazosin HCl
Pregnancy Category: B
0.4 mg capsules
Antagonist of the alpha1A-adrenergic receptors located in the prostate. Blockage of alpha1A-adrenergic receptors can cause smooth muscles in the bladder outlet and the prostate gland to relax, resulting in improvement
in urinary blood flow and a reduction in symptoms of BPH.
Effectiveness is indicated by improved voiding. Improves symptoms related to benign prostatic hypertrophy (BPH) related
to bladder outlet obstruction.
Benign prostatic hypertrophy.
Hypersensitivity to tamsulosin; in conjunction with another alpha1A-adrenergic blocking agent; women; lactation, pediatric patients.
History of syncope, hypersensitivity to sulfonamides; hypotension; older adults; renal impairment, renal failure, renal
disease; pregnancy (category B).
Route & Dosage
|Benign Prostatic Hypertrophy
Adult: PO 0.4 mg q.d. 30 min after a meal, may increase up to 0.8 mg q.d.
- Give 30 min after the same meal each day.
- Instruct to swallow capsules whole; not to crush, chew, or open.
- If dose is interrupted for several days, reinitiate at the lowest dose, 0.4 mg.
- Store at 20°25° C (68°77° F).
Adverse Effects (≥1%)Body as a Whole:
Asthenia, back or chest pain. CNS: Headache, dizziness, insomnia
. CV: Orthostatic hypotension (especially with first dose). GI: Diarrhea
, nausea. Respiratory: Rhinitis,
pharyngitis, increased cough, sinusitis
Decreased libido, abnormal ejaculation. Special Senses:
may decrease clearance of tamsulosin. Sildenafil, vardenafil,
may enhance hypotensive effects.
Rapidly from GI tract. >90% bioavailability. Peak:
45 h fasting, 67 h fed. Distribution:
Widely distributed in body tissues, including kidney and prostate. Metabolism:
In the liver. Elimination:
76% in urine. Half-Life:
Assessment & Drug Effects
- Monitor for signs of orthostatic hypotension; take BP lying down, then upon standing. Report a systolic pressure drop of
≥15 mm Hg or a HR ≥15 beats
- Monitor patients on warfarin therapy closely.
Patient & Family Education
- Make position changes slowly to minimize orthostatic hypotension.
- Report dizziness, vertigo, or fainting to physician. Exercise caution with hazardous activities until response to drug is
- Be aware that concurrent use of cimetidine may increase the orthostatic hypotension adverse effect.