SODIUM PHENYLBUTYRATE

(SOE dee um FEN il BUE ti rate) Brand: Buphenyl

What is the most significant information I must know about sodium phenylbutyrate?

• Even with treatment, urea cycle disorders can reason a build-up of ammonia in the blood which can result in life-threatening side effects. Seek abnormal medical attention if you announcement any signs of ammonia build-up, including mood or behavior changes, memory loss, thinking problems, muscle twitching, back and forth movement of the eyes, vomiting, increasing weakness, slurred speech, seizure (convulsions), and fainting.

• Till taking sodium phenylbutyrate, speak your doctor if you have congestive heart failure, tall blood pressure, severe kidney malady, swelling or fluid retention, or a seizure disorder.

• Take this medicine with every meal. Divide your total daily doze among all of your meals for the day.

• Sodium phenylbutyrate is only part of a complete program of treatment that may also include diet, dialysis, or another medications. Follow your diet and medicine routines very closely.

• Do not give this medicine to a baby who weighs smaller than 44 pounds unless your doctor tells you to.

What is sodium phenylbutyrate?

• Sodium phenylbutyrate is converted to a stuff in the body that helps the kidneys eliminate waste substances from the body. These waste substances can manufacture ammonia, which is toxic if it builds up in your blood.

• Sodium phenylbutyrate is used to treat urea cycle disorders in people who lack determined liver enzymes needed to properly eliminate waste substances from the body. This medicine helps prevent a build-up of ammonia in the blood.

• Sodium phenylbutyrate may also be used for another purposes not listed in this medicine guide.

What must I discuss with my health care provider till taking sodium phenylbutyrate?

• Till using sodium phenylbutyrate, speak your doctor if you are allergic to any drugs, or if you have:

· congestive heart failure;

· tall blood pressure;

· severe kidney disease;

· swelling or fluid retention; or

· epilepsy or another seizure disorder.

• If you have any of these conditions, you may not be able to take sodium phenylbutyrate, or you may need a doze adjustment or particular trials to safely take this medication.

• Your doctor will speak you if any of your medicine doses need to be changed.

• FDA pregnancy category C. It is not known whether sodium phenylbutyrate is deleterious to an unborn child. Speak your doctor if you are pregnant or plan to become pregnant during treatment.

• It is not known whether sodium phenylbutyrate passes into breast milk or if it could harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

• Do not give this medicine to a baby who weighs smaller than 44 pounds unless your doctor tells you to.

How must I take sodium phenylbutyrate?

• Take this medicine exactly as predesigned by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

• Take this medicine with every meal. Divide your total daily doze among all of your meals for the day.

• Sodium phenylbutyrate powder must be mixed with food till consuming.

• Shake the powder lightly till mixing it with food.

• Do not stop using this medicine without your doctor's advice, even if you feel better. If the urea cycle mess is not under control, you may have a build-up of ammonia, which can reason life-threatening side effects.

• Call your doctor right away if you have any signs of infection such as fever, chills, redness, swelling, body aches, or weakness. An infection may reason your condition to go out of control even while you are taking sodium phenylbutyrate.

• You may need to take sodium phenylbutyrate for the rest of your life. It is significant to use the medicine regularly to get the most benefit. Get your prescription refilled till you run out of medication completely.

• Sodium phenylbutyrate is only part of a complete program of treatment that may also include diet, dialysis, or another medications. Follow your diet and medicine routines very closely.

• Store sodium phenylbutyrate at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. If it is nearly time for your following doze, wait before then to take the medication and skip the missed doze. Do not take extra medication to create up the missed dose.

• Be certain to take the medicine with food.

What happens if I overdose?

• Search abnormal medical attention if you think you have used too many of this medicine.

• Symptoms of a sodium phenylbutyrate overdose are not known.

What must I avoid while taking sodium phenylbutyrate?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using sodium phenylbutyrate.

What are the possible side effects of sodium phenylbutyrate?

• Even with treatment, urea cycle disorders can reason a build-up of ammonia in the blood which can result in life-threatening side effects. Seek abnormal medical attention if you announcement any signs of ammonia build-up, including mood or behavior changes, memory loss, thinking problems, muscle twitching, back and forth movement of the eyes, vomiting, increasing weakness, slurred speech, seizure (convulsions), and fainting.

• Get abnormal medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Stop using sodium phenylbutyrate and call your doctor at once if you have any of these serious side effects:

• Call your doctor at once if you have a serious side effect such as:

· quick, slow, or uneven heart rate;

· swelling, rapid weight gain;

· feeling like you might pass out; or

· changes in mood, personality, or behavior.

• Smaller serious side effects may include:

· changes in menstrual periods;

· loss of appetite;

· headache;

· heighten body odor;

· unusual or unpleasant taste in your mouth.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect sodium phenylbutyrate?

• The next drugs can interact with sodium phenylbutyrate. Speak your doctor if you are using any of these:

· valproic acid (Depakene);

· haloperidol (Haldol);

· probenecid (Benemid); or

· steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others.

• This list is not complete and there may be another drugs that can interact with sodium phenylbutyrate. Speak your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal commodity, and drugs predesigned by another doctors. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about sodium phenylbutyrate.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.