SODIUM NITRITE AND SODIUM THIOSULFATE

(SOO dee um NYE trite and SOO de um THYE oh SUL fate) Brand: Nithiodote

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What is the most significant information I must know about sodium nitrite and sodium thiosulfate?

• If possible till you receive sodium nitrite and sodium thiosulfate, speak your caregivers if you have anemia, low blood pressure, or heart malady.

• In an abnormal situation it may not be possible till you are treated to speak your caregivers about your health conditions or if you are pregnant or breast feeding. Create certain any doctor caring for you afterward knows that you have received this medication.

What is sodium nitrite and sodium thiosulfate?

Sodium nitrite and sodium thiosulfate is a combination medication that is used as an antidote to cyanide poisoning. Sodium nitrite and sodium thiosulfate works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

Sodium nitrite and sodium thiosulfate is used in an abnormal to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a home or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin.

Sodium nitrite and sodium thiosulfate may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till receiving sodium nitrite and sodium thiosulfate?

• If possible till you receive sodium nitrite and sodium thiosulfate, speak your caregivers if you have:

· anemia (low red blood cells);

· a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;

· low blood pressure; or

· heart disease.

• FDA pregnancy category C. Speak your doctor if you are pregnant. It is not known whether sodium nitrite and sodium thiosulfate will harm an unborn child. However, the benefits of treating cyanide poisoning may outweigh any risks posed by this medicine, for both you and your child.

• It is not known whether this medicine passes into breast milk or if it could harm a nursing child. You must not breast-feed shortly after you have been treated with sodium nitrite and sodium thiosulfate. Ask your doctor how long you must wait till breast-feeding again. If you use a breast exhaust during this time, throw out any milk you collect. Do not feed it to your child.

• In an abnormal situation, it may not be possible till you are treated with sodium nitrite and sodium thiosulfate to speak your caregivers if you are pregnant or breast feeding. Create certain any doctor caring for your pregnancy or your child knows you have received this medication.

How is sodium nitrite and sodium thiosulfate given?

• This medicine is injected into a vein through an IV. You will receive this injection in a clinic or abnormal setting.

Sodium nitrite and sodium thiosulfate are given as two separate injections.

• Your breathing, blood pressure, oxygen levels, heart function, and another vital signs will be watched closely while you are receiving sodium nitrite and sodium thiosulfate.

What happens if I miss a dose?

• Since sodium nitrite and sodium thiosulfate is given by a healthcare professional in an abnormal setting, you are not likely to miss a dose.

What happens if I overdose?

• Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What must I avoid after receiving sodium nitrite and sodium thiosulfate?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of sodium nitrite and sodium thiosulfate?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; chest tightness, difficulty breathing; swelling of your person, lips, tongue, or throat.

• Speak your caregivers right away if you have a serious side effect such as:

· feeling like you might pass out;

· headache, weary feeling, blue-colored skin, feeling short of breath;

· quick or irregular heart course; or

· pounding heartbeats or fluttering in your chest.

• Smaller serious side effects may include:

· mild dizziness;

· blurred vision;

· confusion, anxiety, sweating;

· nausea, vomiting, stomach pain;

· salty taste in your mouth;

· feeling of warmth; or

· tingly feeling where the injection was given.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect sodium nitrite and sodium thiosulfate?

• If possible till you receive this medicine, speak your doctor about all another medicines you use, especially:

· blood pressure medication;

· a diuretic (water pill); or

· sildenafil (Viagra), tadalafil (Cialis), and another erectile dysfunction medicines.

• There may be another drugs that can interact with sodium nitrite and sodium thiosulfate. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist can provide more information about sodium nitrite and sodium thiosulfate.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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