Raised INRs and/or bleeding have been seen in patients taking
warfarin with esomeprazole,
lansoprazole or
omeprazole, and acenocoumarol with
omeprazole, but on the whole the
proton pump inhibitors do not appear to have any clinically significant interactions with these anticoagulants.
Any interaction seems rare, but bear the possibility in mind in case of an excessive response to anticoagulation.