(peg LOE ti kase) Brand: Krystexxa
• You must not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Some drugs can interact with pegloticase and must not be used at the same time, especially allopurinol (Zyloprim), probenecid (Benemid), or febuxostat (Uloric).
• To create certain pegloticase is safety for you, speak your doctor if you have gout, congestive heart failure, another heart problems, or tall blood pressure.
• You may be given another medications to prevent determined side effects of pegloticase. You may need to start taking these medications at least a week till you receive your pegloticase injection. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice.
• Speak your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a quick heartbeat, chest discomfort, or redness of your skin when the medication is injected into your vein.
• Pegloticase is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine.
• Pegloticase is used to treat chronic gout. Pegloticase is generally given after another gout medications have been tried without successful treatment of symptoms.
• Pegloticase may also be used for purposes not listed in this medicine guide.
• You must not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Some drugs can interact with pegloticase and must not be used at the same time. Speak your doctor about all another medications you use, especially:
· allopurinol (Zyloprim);
· probenecid (Benemid); or
· febuxostat (Uloric).
• To create certain pegloticase is safety for you, speak your doctor about your another medical conditions, especially:
· gout;
· congestive heart failure;
· another heart problems; or
· tall blood pressure.
• FDA pregnancy category C. It is not known whether pegloticase will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.
• It is not known whether pegloticase passes into breast milk or if it could harm a nursing child. You must not breast-feed while you are using pegloticase.
• Pegloticase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Pegloticase should be given slowly, and the IV infusion can take at least 2 hours to complete.
• You may be given another medications to prevent determined side effects of pegloticase. You may need to start taking these medications at least a week till you receive your pegloticase injection. Read the medicine manual or patient instructions provided with every medicine. Do not change your doses or medicine schedule without your doctor's advice.
• Pegloticase is generally given once each 2 weeks. Follow your doctor's dosing instructions very carefully.
• When you first start using pegloticase, you may have an magnify in gout flares. Hold using the medicine as directed and speak your doctor if your symptoms do not improve after 3 months of treatment.
• Your doctor may recommend another gout medications during the first 6 months of your treatment with pegloticase.
• To be certain this medicine is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with pegloticase. Visit your doctor regularly.
• Call your doctor for instructions if you miss an appointment for your pegloticase injection.
• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.
• Follow your doctor's instructions about any restrictions on food, beverages, or activity.
• Some people receiving a pegloticase injection have had a reaction to the infusion (when the medication is injected into the vein). Infusion reactions may also occur after the injection is given. Speak your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a quick heartbeat, chest discomfort, or redness of your skin during the injection.
• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your person, lips, tongue, or throat.
• Call your doctor at once if you have a serious side effect such as:
· chest pain; or
· flushing (warmth, redness, or tingly feeling).
• Smaller serious side effects may include:
· new gout flares;
· nausea, vomiting, constipation;
· light bruising; or
· stuffy nose, sore throat.
• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.
• There may be another drugs that can interact with pegloticase. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.
• Your pharmacist can provide more information about pegloticase.
Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.