| PAREGORIC (CAMPHORATED OPIUM TINCTURE)
Classifications: antidiarrheal; narcotic (opiate) agonist analgesic; Therapeutic: antidiarrheal; opiate
Pregnancy Category: C
Controlled Substance: Schedule III
2 mg/5 mL liquid
Contains 2 mg anhydrous morphine, alcohol, benzoic acid, camphor, and anise oil. Pharmacologic activity is due to morphine
content. Increases smooth muscle tone of GI tract, decreases motility and effective propulsive peristalsis while diminishing
Delayed transit of intestinal contents results in desiccation of feces and constipation.
Short-term treatment for symptomatic relief of acute diarrhea and abdominal cramps.
Hypersensitivity to opium alkaloids; diarrhea caused by poisons (until eliminated); COPD; pregnancy (category C).
Asthma; liver disease; GI disease; history of opiate agonist dependence; severe prostatic hypertrophy, lactation.
Route & Dosage
Adult: PO 510 mL after loose bowel movement, 14 times daily if needed
Child: PO 0.250.5 mL/kg 14 times/d
- Give paregoric in sufficient water (2 or 3 swallows) to ensure its passage into the stomach (mixture will appear milky).
Adverse Effects (≥1%)GI:
Anorexia, nausea, vomiting, constipation,
abdominal pain. Body as a Whole:
Dizziness, faintness, drowsiness, facial flushing, sweating, physical dependence.
and other cns depressants
add to CNS
Readily from GI tract. Duration:
45 h. Distribution:
Crosses placenta; distributed into breast milk. Metabolism:
In liver. Elimination:
In urine. Half-Life:
Assessment & Drug Effects
- Paregoric may worsen the course of infection-associated diarrhea by delaying the elimination of pathogens.
- Be aware that adverse effects are primarily due to morphine content. Paregoric abuse results because of the narcotic content
of the drug.
- Assess for fluid and electrolyte imbalance until diarrhea has stopped.
Patient & Family Education
- Adhere strictly to prescribed dosage schedule.
- Maintain bed rest if diarrhea is severe with a high level of fluid loss.
- Replace fluids and electrolytes as needed for diarrhea. Drink warm clear liquids and avoid dairy products, concentrated
sweets, and cold drinks until diarrhea stops.
- Observe character and frequency of stools. Discontinue drug as soon as diarrhea is controlled. Report promptly to physician
if diarrhea persists more than 3 d, if fever is >38.8° C (102° F), abdominal pain develops, or if mucus or blood
- Understand that constipation is often a consequence of antidiarrheal treatment and a normal elimination pattern is usually
established as dietary intake increases.