Numorphan, Opana, Opana ER
Classifications: narcotic (opiate) agonist; analgesic; Therapeutic: narcotic analgesic
Pregnancy Category: C
Controlled Substance: Schedule II
1 mg/mL, 1.5 mg/mL injection; 5 mg suppositories; 10 mg extended release tablets; 10 mg tablets
Structurally and pharmacologically related to morphine. Analgesic action for moderate to severe pain. Produces mild sedation
and, unlike morphine, has little antitussive action.
Effective in relief of moderate to severe pain.
Relief of moderate to severe pain, preoperative medication, obstetric analgesia, support of anesthesia, and relief of anxiety
in patients with dyspnea associated with acute ventricular failure and pulmonary edema.
Pulmonary edema resulting from chemical respiratory irritants; ileus; status asthmaticus; pregnancy (category C), children
Alcoholism; biliary tract disease; bladder obstruction; severe pulmonary disease, respiratory insufficiency, COPD; depression;
older adults; lactation.
Route & Dosage
|Moderate to Severe Pain
Adult: PO 1020 mg q46h prn; extended release 510 mg q12h SC/IM 11.5 mg q46h prn IV 0.5 mg q46h PR 5 mg q46h prn
Analgesia during Labor
Adult: IM 0.51 mg
PREPARE: Direct: Dilute in 5 mL of sterile water or NS.
ADMINISTER: Direct: Give at a rate of 0.5 mg over 25 min.
- Protect drug from light. Store suppositories in refrigerator 2°15° C (36°59° F).
Adverse Effects (≥1%)GI: Nausea, vomiting, euphoria. CNS: Dizziness,
lightheadedness, sedation. Respiratory: Respiratory depression
(see morphine), apnea, respiratory arrest. Body as a Whole:
Sweating, coma, shock. CV: Cardiac arrest,
and other cns depressants
add to CNS depression; propofol
increases risk of bradycardia.
510 min IV; 1015 min IM; 1530 min PR. Peak:
11.5 h. Duration:
36 h. Distribution:
Crosses placenta. Metabolism:
In liver. Elimination:
In urine. Half-Life:
PO 79 h; extended release 911 h.
Assessment & Drug Effects
- Monitor respiratory rate. Withhold drug and notify physician if rate falls below 12 breaths per min.
- Supervise ambulation and advise patient of possible light-headedness. Older adult and debilitated patients are most susceptible
to CNS depressant effects of drug.
- Evaluate patient's continued need for narcotic analgesic. Prolonged use can lead to dependence of morphine type.
- Medication contains sulfite and may precipitate a hypersensitivity reaction in susceptible patient.
Patient & Family Education
- Use caution when walking because of potential for injury from dizziness.
- Do not consume alcohol while taking oxymorphone.