On the whole the concurrent use of
NSAIDs and
opioids is successful and without incident. The following specifically studied pairs have not been found to interact adversely: alfentanil with parecoxib,
codeine with diclofenac, dextropropoxyphene (propoxyphene) with meclofenamate, dextropropoxyphene (propoxyphene) with
sulindac, fentanyl with parecoxib, methadone with
intramuscular diclofenac, and morphine with
ketoprofen. There seems no reason to assume other
NSAIDs and
opioids will interact. However, see the specific instances discussed below.
No action needed.