Classifications: analgesic, nonsteroidal antiinflammatory drug (nsaid); antipyretic; Therapeutic: nsaid, analgesic
Pregnancy Category: B
25 mg, 50 mg, 75 mg capsules; 100 mg, 150 mg, 200 mg sustained release capsules
Nonsteroidal antiinflammatory drug (NSAID) that inhibits both COX-1 and COX-2 enzymes; thus it also inhibits prostaglandin
synthesis, and therefore interferes with the inflammatory process. It inhibits platelet aggregation and prolongs bleeding
Has analgesic, antiinflammatory, and antiplatelet properties.
Acute or long-term treatment of rheumatoid arthritis and osteoarthritis; primary dysmenorrhea; headache; symptomatic relief
of postoperative, dental, and postpartum pain; visceral pain associated with cancer.
Reiter's syndrome, juvenile arthritis, acute gouty arthritis, biliary pain, renal colic.
Patient in whom aspirin or another NSAID induces asthma, urticaria, bronchospasm, severe rhinitis, shock; renal nephritis,
nephritic syndrome. Safety in children <16 y is not established.
History of GI disease, GI bleeding, active ulcer; renal or hepatic impairment, patient who may be adversely affected by
prolongation of bleeding time; heart failure, fluid retention; hypertension; patient receiving diuretics; geriatric patient;
myasthenia gravis; pregnancy (category B).
Route & Dosage
Adult: PO 75 mg t.i.d. or 50 mg q.i.d. (max: 300 mg/d) or 200 mg sustained release q.d.
Geriatric: PO Start with 25 mg q.i.d., may also start with 50 mg t.i.d.
Mild to Moderate Pain, Dysmenorrhea
Adult: PO 12.550 mg q68h
- Do not crush.
- Give with food, milk, or prescribed antacid to reduce GI irritation.
- Store drug at 15°30° C (59°86° F) in tightly closed, light-resistant container unless otherwise
Adverse Effects (≥1%)CNS:
Trouble in sleeping, nervousness, headache,
, drowsiness, confusion, migraine, vertigo. CV:
Peripheral edema, palpitations, hypertension, tachycardia. Special Senses:
Visual disturbances, conjunctivitis
, eye pain, retinal hemorrhage, pigmentation changes; Dry nose or throat, tinnitus, hearing
impairment. GI: Dyspepsia, drug-induced peptic ulcer, GI bleeding,
nausea, vomiting, diarrhea, constipation
, flatulence, stomach pain, anorexia, dry mouth, gingivitis, rectal burning and
hemorrhage, melena, jaundice
, elevated ALT, AST. Hematologic:
Prolonged bleeding time, anemia, purpura, agranulocytosis,
Gynecomastia, changes in libido, urinary tract irritation (dysuria, frequency/urgency), renal
impairment. Respiratory: Laryngospasm, bronchospasm, laryngeal edema,
Rash, pruritus, urticaria, erythema, photosensitivity. Endocrine:
Aggravation of diabetes
InteractionsDrug: oral anticoagulants
may prolong bleeding time; may increase lithium
toxicity; may increase methotrexate
toxicity. Herbal: Feverfew, garlic, ginger, ginkgo
increases bleeding potential.
Readily from GI tract. Onset:
12 h. Peak:
12 h. Duration:
46 h. Metabolism:
In liver. Elimination:
Primarily in urine, some biliary excretion. Half-Life:
Assessment & Drug Effects
- Lab tests: Monitor baseline and periodic evaluations of hemoglobin, renal and hepatic function.
- Monitor for and report tinnitus, hearing impairment, and visual disturbance, especially during prolonged or high-dose therapy.
- Monitor for S&S of GI ulceration (e.g., stool for occult blood, persistent indigestion).
Patient & Family Education
- Report promptly signs of jaundice (see Appendix F) as well as the following: blurred vision, tinnitus, urinary urgency or
frequency, unexplained bleeding, weight gain with edema.
- Note: Possible CNS adverse effects (e.g., light-headedness, dizziness, drowsiness).
- Do not drive or engage in potentially hazardous activities until response to drug is known.
- Note: Alcohol, aspirin, or other NSAIDs may increase risk of GI ulceration and bleeding tendencies and therefore should be avoided.
- Tell dentist or surgeon that you are taking ketoprofen.