MITOXANTRONE HYDROCHLORIDE (mi-tox'an-trone) Novantrone Classifications: antineoplastic; antibiotic; immunosuppressant; Therapeutic: antineoplastic; immunosuppressant Prototype: Doxorubicin Pregnancy Category: D |
2 mg/mL injection
Non-cell-cycle specific antitumor agent with less cardiotoxicity than doxorubicin. Interferes with DNA synthesis by intercalating with the DNA double helix, blocking effective DNa and RNA transcription.
Highly destructive to rapidly proliferating cells in all stages of cell division.
In combination with other drugs for the treatment of acute nonlymphocytic leukemia (ANLL) in adults, bone pain in advanced prostate cancer. Reducing neurologic disability and/or the frequency of clinical relapses in patients with multiple sclerosis.
Breast cancer, non-Hodgkin's lymphomas.
Hypersensitivity to mitoxantrone; myelosuppression; multiple sclerosis; baseline LVEF less than 50%; pregnancy (category D), lactation.
Impaired cardiac function; impaired liver and kidney function; systemic infections.
Combination Therapy for ANLL Adult: IV Induction Therapy: 12 mg/m2/d on days 13, may need to repeat induction course IV Consolidation Therapy: 12 mg/m2 on days 1 and 2 (max: lifetime dose 80120 mg/m2) Prostate Cancer Adult: IV 1214 mg/m2 q21d Multiple Sclerosis Adult: IV 12 mg/m2 over 515 min q3mo (max: lifetime dose 140 mg/m2) |
Intravenous
PREPARE: IV Infusion: ??Must be diluted prior to use. Withdraw contents of vial and add to at least 50 mL of D5W or NS. May be diluted to larger volumes to extend infusion time. ??Use goggles, gloves, and protective gown during drug preparation and administration. ADMINISTER: IV Infusion: Administer into the tubing of a freely running IV of D5W or NS and infused over at least 3 min or longer (i.e., 3060 min) depending on the total volume of IV solution. If extravasation occurs, stop infusion and immediately restart in another vein. INCOMPATIBILITIES Solution/additive: Heparin, hydrocortisone, paclitaxel. Y-site: Amphotericin B cholesteryl complex, aztreonam, cefepime, doxorubicin liposome, paclitaxel, piperacillin/tazobactam, propofol, TPN. |
Assessment & Drug Effects
Patient & Family Education