AZTREONAM (az-tree'oh-nam) Azactam Classifications: antibiotic; beta-lactam antibiotic; Therapeutic: antibiotic Prototype: Imipenem-cilastatin Pregnancy Category: B |
500 mg, 1 g, 2 g vials
Differs structurally from other beta-lactam antibiotics (penicillins and cephalosporins) in having a monocyclic rather than a bicyclic nucleus. Acts by inhibiting synthesis of bacterial cell wall by preferentially binding to specific penicillin-binding proteins (PBP) in the bacterial cell wall.
Highly resistant to beta-lactamases and does not readily induce their formation. Spectrum of activity limited to aerobic, gram-negative bacteria.
Gram-negative infections of urinary tract, lower respiratory tract, skin and skin structures; and for intraabdominal and gynecologic infections, septicemia, and as adjunctive therapy for surgical infections. Often used in combination with other antibiotics active against gram-positive and anaerobic bacteria in mixed infections.
Lactation, viral infections.
History of hypersensitivity reaction to penicillin, cephalosporins, or to other drugs; impaired renal or hepatic function, elderly; pregnancy (category B).
Urinary Tract Infection Adult: IV/IM 0.51 g q812h Moderate to Severe Infections Adult: IV/IM 12 g q812h (max: 8 g/24 h) Child: IV 30 mg/kg/d q68h Cystic Fibrosis Child: IV/IM 50 mg/kg q68h (max: 8 g/d) Renal Impairment Clcr 1030 mL/min: reduce dose 50%; <10mL/min: reduce dose by 75% Hemodialysis: Reduce dose to 12.5% and give after hemodialysis |
Intravenous Verify correct IV concentration and rate of infusion/injection with physician before giving to neonates, infants, and children. PREPARE: Direct: ?? Reconstitute a single dose with 610 mL of sterile water for injection. ??Immediately shake vial until solution is dissolved. May be given direct IV as prepared or further diluted for IV infusion.??Reconstituted solutions are colorless to light straw yellow and turn slightly pink on standing. Intermittent: Each gram of reconstituted aztreonam must be further diluted in at least 50 mL of D5W, NS, or other solution approved by manufacturer to yield a concentration not to exceed 20 mg/mL. ADMINISTER: Direct: Give over 35 min. Intermittent: Give over 2060 min through Y-site. INCOMPATIBILITIES Solution/additive: Ampicillin, metronidazole, nafcillin. Y-site: Acyclovir, amphotericin B, amphotericin b cholesteryl complex, amsacrine, azithromycin, chlorpromazine, daunorubicin, ganciclovir, lansoprazole, lorazepam, metronidazole, mitomycin, mitoxantrone, streptozocin. |
Aztreonam may cause transient elevations of liver function tests, increases in PT and PTT, minor changes in Hgb, and positive Coombs' test.
Assessment & Drug Effects
Patient & Family Education