Clarithromycin almost doubles the
serum levels of esomeprazole,
lansoprazole and
omeprazole. A small rise in the
serum levels of
clarithromycin also occurs, which may be therapeutically useful. Some very limited evidence indicates that
erythromycin causes a larger rise in
serum omeprazole levels, without improving its gastric acid lowering effect.
Given the wide use of Helicobacter pylori eradication regimens containing these drugs it seems unlikely that this interaction is detrimental.