Isopap, Duradrin, Midrin, Migratine
Classifications: sympathomimetic; analgesic, nonnarcotic; Therapeutic: antimigraine; analgesic, non-narcotic
Pregnancy Category: C
Controlled Substance: Schedule Schedule C-IV
isometheptene mucate, 100 mg
dichloralphenazone, 325 mg
Isometheptene is a sympathomimetic amine that acts by constricting cranial and cerebral arterioles. Isometheptene relieves
vascular headaches. Dichloralphenazone is a mild sedative that helps reduce headache pain. Acetaminophen is a mild analgesic.
Effective as a mild sedative, reduces headache pain as well as being a mild analgesic.
Relief for tension, vascular, and migraine headaches.
Patients with glaucoma; severe renal disease, organic heart disease; hepatic disease; concurrent MAO inhibitors; pregnancy
(category C), lactation.
Hypertension; peripheral vascular disease, and recent cardiovascular attacks; older adults; pulmonary disease.
Route & Dosage
Adult: PO 12 capsules q4h up to 8 capsules/24 h
Adult: PO 2 capsules at onset, then 1 capsule qh until relief (max: 5 capsules/12 h)
- Do not give this drug to anyone who is concurrently using an MAOI. Allow 14 d to elapse between discontinuation of the MAOI and administration of this drug.
- Do not give more than 8 capsules in a 24 h period.
- Store at 15°30° C (59°86° F) in a dry place.
Adverse Effects (≥1%)CNS:
Transient dizziness. GI:
Acetaminophen hepatotoxicity. Skin:
s may cause hypertensive crisis; other acetaminophen
-containing drugs (including OTC) may increase risk of hepatotoxicity.
Rapidly absorbed. Metabolism:
Dichloralphenazone is metabolized to chloral hydrate
and antipyrine. See ACETAMINOPHEN
and CHLORAL HYDRATE
for more detail. Elimination: Renal
Assessment & Drug Effects
- Monitor BP closely with preexisting hypertension.
- Monitor lower extremity perfusion with a history of PVD.
Patient & Family Education
- Avoid, or moderate, alcohol use while taking this drug.
- Do not drive or engage in other potentially hazardous activities until response to drug is known.
- Report any decrease in tolerance to walking if you have a history of PVD.