Dihydrocodeinone Bitartrate, Hycodan, Robidone A, Vicodin (with acetaminophen)
Classifications: narcotic (opiate) agonist analgesic; antitussive; Therapeutic: narcotic analgesic
Pregnancy Category: C
Controlled Substance: Schedule III
5 mg hydrocodone usually with 500 mg or more acetaminophen
Morphine derivative similar to codeine but more addicting and with slightly greater antitussive activity, and analgesic
effect. CNS depressant with moderate to severe relief of pain. Available in the United States only in combination with other
Suppresses cough reflex by direct action on cough center in medulla. CNS depressant with moderate to severe relief of pain.
Symptomatic relief of hyperactive or nonproductive cough and for relief of moderate to moderately severe pain. A common ingredient
in a variety of proprietary mixtures.
Hypersensitivity to hydrocodone; children <2 y; pregnancy (category C); acute or severe asthmatic bronchitis; COPD; upper
airway obstruction; lactation.
Respiratory depression, asthma, emphysema; history of drug abuse or dependence; postoperative patients; hepatic or renal
disease; renal impairment or failure; older adults, debilitated patients; children <1 y; patients; children weighing <50
kg; G6PD deficiency; GI disease; patients with preexisting increased intracranial pressure.
Route & Dosage
|Mild to Moderate Pain, Cough
Adult: PO 510 mg q46h prn (max: 15 mg/dose)
Child (212 y): PO 1.255 mg q46h (max: 10 mg/dose)
- Give with food or milk to prevent GI irritation.
- Preserve in tight, light-resistant containers.
Adverse Effects (≥1%)GI:
Dry mouth, constipation, nausea,
Light-headedness, sedation, dizziness, drowsiness,
euphoria, dysphoria. Respiratory: Respiratory depression. Skin:
Urticaria, rash, pruritus.
and other cns depressants
compound sedation and CNS depression
. Herbal: St. John's wort
1020 min. Duration:
36 h. Distribution:
Crosses placenta; distributed into breast milk. Metabolism:
In liver. Elimination:
In urine. Half-Life:
Assessment & Drug Effects
- Monitor for effectiveness of drug for pain relief.
- Monitor for nausea and vomiting, especially in ambulatory patients.
- Monitor respiratory status and bowel elimination.
Patient & Family Education
- Avoid hazardous activities until response to drug is determined.
- Do not use alcohol or other CNS depressants; may cause additive CNS depression.
- Drink plenty of liquids for adequate hydration.
- Do not take larger doses than prescribed since abuse potential is high.