Classifications: nitrofuran antibiotic; Therapeutic: antibiotic
Pregnancy Category: C
100 mg tablets; 50 mg/15 mL liquid
Synthetic nitrofuran with antibacterial and antiprotozoal properties. Acts by interfering with several bacterial enzyme systems
including cell wall synthesis of bacteria.
Bactericidal against majority of GI pathogens, gram-positive and gram-negative bacteria, as well as protozoa.
Bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
Hypersensitivity to furazolidone, concurrent use with alcohol, MAO INHIBITOR, tyramine-containing foods, indirect-acting sympathomimetic amines; infants <1 mo; neonates; pregnancy (category C), lactation.
If at all, patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to possible development of reversible hemolysis.
Route & Dosage
|Diarrhea and Enteritis
Adult: PO 100 mg q.i.d.
Child: PO 1 mo1 y, 817 mg q.i.d.; 14 y, 1725 mg q.i.d.; ?5 y, 2550 mg q.i.d. (max: 8.8 mg/kg/d)
- Store in tight, light-resistant containers (drug darkens on exposure to light). Protect from excessive heat.
Adverse Effects (≥1%)GI: Nausea, vomiting,
abdominal pain, diarrhea. Hypersensitivity:
Fever, arthralgia, hypotension, urticaria, angioedema, vesicular or morbilliform rash. Body as a Whole:
Headache, malaise, dizziness, hypoglycemia
Intravascular hemolysis in patients with G6PD deficiency, agranulocytosis (rare)
. Special Senses:
Diagnostic Test Interference
Furazolidone metabolite reportedly may cause false-positive reactions for urine glucose with copper sulfate reduction methods, (e.g., Benedict's reagent, Clinitest, and Fehling's solution).
may elicit disulfiram-type reaction up to 4 d after the drug is stopped; mao inhibitors
, sympathomimetic amines
, ephedrine, phenylpropanolamine
may cause a hypertensive reaction; tricyclic antidepressants
may cause toxic psychosis. Food:
may interact with tyramine-containing foods, resulting in flushing, tachycardia, and hypertensive crisis. See phenelzine
prototype). Herbal: Ginseng
may cause hypertension, manic symptoms, headaches, nervousness; ma-huang, ephedra, St. John's wort
may lead to hypertensive crisis.
Poorly absorbed from GI tract. Metabolism:
In intestines. Elimination:
Assessment & Drug Effects
- Monitor for nausea and vomiting. Dosage reduction may be needed.
- Note: Bed rest, fluid and electrolyte replacement (as indicated) are important adjuncts to therapy. Consult physician regarding
- Keep physician informed of S&S of dehydration (see Appendix F) and electrolyte imbalance.
- Monitor patients for lost glycemic control because drug may cause hypoglycemia (see Appendix F). Use glucose oxidase methods
for urine testing (e.g., Clinistix, Diastix, TesTape).
Patient & Family Education
- Report the following to physician: Faintness, weakness, and light-headedness. These may be symptoms of hypersensitivity reaction
- Be aware of and avoid foods high in tyramine (e.g., aged and fermented food and drinks) that may produce hypertensive reaction.
Hypertensive crisis is most likely to occur when drug is continued beyond 5 d or when large doses are given.
- Do not drink alcohol during furazolidone therapy and for at least 4 d after drug is stopped. Ingestion of alcohol may cause
disulfiram-type reaction (see Appendix F); symptoms may last up to 24 h.
- Note: Drug may impart a harmless brown color to urine.
- Monitor blood glucose for loss of glucemic control if diabetic.