Food reduces the rate of absorption but has no or little effect on the extent of absorption of most
NSAIDs. The extent of
ketoprofen absorption is reduced by food.
The small changes seen will have no
clinical relevance if these drugs are being used regularly to treat chronic pain and inflammation. However, if they are being used for the treatment of acute pain,
administration on an empty stomach would be preferable in terms of onset of effect. However, it is usually recommended that
NSAIDs (including ketoprofen) are given with or after food, in an attempt to minimise their
gastrointestinal adverse effects.