Flumazenil (Romazicon); Antidote - Benzodiazepine; Vial: 0.1 mg/mL [5, 10 mL];
Reversal of benzodiazepine: Children: 0.01 mg/kg
IV (max 0.2mg),
repeat as needed
Adolescents: 0.2 mg
IV over 30 seconds, wait 30 seconds, then give 0.3-0.5 mg over 30 seconds if needed
Continuous infusion: 0.005-0.01 mg/kg/hr
May need to repeat doses because the
half-life of
flumazenil may be significantly shorter than the
half-life of the benzodiazepine being reversed.